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. 2013 Feb;38(2):188-200.
doi: 10.1016/j.psyneuen.2012.05.013. Epub 2012 Jun 21.

Childhood adversity and inflammatory processes in youth: a prospective study

Natalie Slopen  1 , Laura D Kubzansky, Katie A McLaughlin, Karestan C Koenen
Affiliations

Childhood adversity and inflammatory processes in youth: a prospective study

Natalie Slopen et al. Psychoneuroendocrinology. 2013 Feb.

Abstract

Background: Retrospective studies show that childhood adversity is associated with systemic inflammation in adulthood. Few prospective studies have examined whether childhood adversity influences inflammation in an observable manner during childhood or adolescence and if these effects are sustained over time.

Methods: Using longitudinal data from the Avon Longitudinal Study of Parents and Children, we examined associations between acute adverse events at seven time points prior to age 8 and inflammation at ages 10 and 15. Inflammatory markers at age 10 included interleukin-6 (IL-6; N=4655) and C-reactive protein (CRP; N=4647), and CRP was measured again at age 15 (N=3286). We further evaluated whether body mass index (BMI), depression, or cigarette smoking mediated associations between adverse events and inflammation.

Results: Adverse events in middle childhood (occurring between ages 6 to 8), as well as cumulative adversity from birth to 8 years, were associated with higher levels of IL-6 and CRP at age 10. Adverse events reported in early childhood (1.5years) or middle childhood, and cumulative adversity from birth through 8years predicted increased levels of CRP at age 15, and these associations persisted after adjustment for CRP at age 10. Some, but not all, of these associations were mediated by BMI.

Conclusions: This study documents that exposure to adverse events prior to age 8 is associated with elevated inflammation at age 10 and in mid-adolescence. These findings provide prospective evidence for a biological mechanism by which early experiences may shape long-term health. Future studies with earlier assessments of inflammation are necessary in order to elucidate potential sensitive periods and mechanisms that link childhood adversity to later disease vulnerability.

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Conflict of interest statement

Conflict of interest

None declared.

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References

    1. Allen J, Rapee R, Sandberg S. Assessment of maternally reported life events in children and adolescents: a comparison of interview and checklist methods. J Psychopathol Behav. 2011:1–12.
    1. Angold A, Costello EJ, Messer SC, Pickles A, Winder F, Silver D. Development of a short questionnaire for use in epidemiological studies of depression in children and adolescents. Int J Methods Psychiatr Res. 1995;5:237–249.
    1. Angold A, Erkanli A, Silberg J, Eaves L, Costello EJ. Depression scale scores in 8–17-year-olds: effects of age and gender. J Child Psychol Psyc. 2002;43:1052–1063. - PubMed
    1. C Reactive Protein Coronary Heart Disease Genetics Collaboration. Association between C reactive protein and coronary heart disease: mendelian randomisation analysis based on individual participant data. BMJ. 2011:342. - PMC - PubMed
    1. Casas JP, Shah T, Cooper J, Hawe E, McMahon AD, Gaffney D, Packard CJ, O’Reilly DS, Juhan-Vague I, Yudkin JS, Tremoli E, Margaglione M, Di Minno G, Hamsten A, Kooistra T, Stephens JW, Hurel SJ, Livingstone S, Colhoun HM, Miller GJ, Bautista LE, Meade T, Sattar N, Humphries SE, Hingorani AD. Insight into the nature of the CRP-coronary event association using Mendelian randomization. Int J Epidemiol. 2006;35:922–931. - PubMed

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