Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2013;18(2):251-61.
doi: 10.1080/1357650X.2012.660164. Epub 2012 Jun 21.

Non-replication of an association of Apolipoprotein E2 with sinistrality

Brian J Piper  1 , Alia L Yasen, Amy E Taylor, Jonatan R Ruiz, J William Gaynor, Catherine A Dayger, Marcela Gonzalez-Gross, Oh D Kwon, Lars-Göran Nilsson, Ian N M Day, Jacob Raber, Jeremy K Miller
Affiliations
Meta-Analysis

Non-replication of an association of Apolipoprotein E2 with sinistrality

Brian J Piper et al. Laterality. 2013.

Abstract

A recent report found that left-handed adolescents were more than three times more likely to have an Apolipoprotein (APOE) ϵ2 allele. This study was unable to replicate this association in young adults (N=166). A meta-analysis of nine other datasets (N=360 to 7559, Power > 0.999) including that of National Alzheimer's Coordinating Center also failed to find an over-representation of ϵ2 among left-handers indicating that this earlier outcome was most likely a statistical artefact.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Forest plot of left handedness in relation to Apolipoprotein E2 allele carriage. Odds ratios (OR) represent odds of being left handed in E2 carriers compared to non carriers. Point estimates and 95% confidence intervals (CI) are represented by circles and horizontal lines respectively. The sizes of the boxes around the point estimate are in proportion to the weight given to each study in the combined studies OR. UCDADC: University of California, Davis, Alzheimer’s Disease Center; NACC: National Alzheimer’s Coordinating Center.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Abdoahi MR, Guthrie PA, Smith GD, Lawlor DA, Ebrahim S, Day IN. Integrated single-label liquid-phase assay of APOE codons 112 and 158 and a lipoprotein study in British women. Clin Chem. 2006;52:1420–1423. - PubMed
    1. Acevedo SF, Piper BJ, Craytor MJ, Benice TS, Raber J. Apolipoprotein E4 and sex affect neurobehavioral performance in primary school children. Pediatr Res. 2010;67:293–299. - PMC - PubMed
    1. Annett M. A model of the inheritance of handedness and cerebral dominance. Nature. 1964;204:59–60. - PubMed
    1. Beekly DL, Ramos EM, Lee WW, Deitrich WD, Jacka ME, Wu J, Hubbard JL, Koepsell TD, Morris JC, Kukull WA. The National Alzheimer’s Coordinating Center (NACC) database: The Uniform Data Set. Alz Dis Assoc Dis. 2007;21:249–258. - PubMed
    1. Bekris LM, Yu CE, Bird TD, Tsuang DW. Genetics of Alzheimer disease. J Geriatr Psychiatry Neurol. 2010;23:213–227. - PMC - PubMed

Publication types

Substances

LinkOut - more resources