Animal models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis
- PMID: 22654421
- PMCID: PMC3353364
- DOI: 10.3748/wjg.v18.i19.2300
Animal models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis
Abstract
Nonalcoholic fatty liver disease (NAFLD) is a condition in which excess fat accumulates in the liver of a patient without a history of alcohol abuse. Nonalcoholic steatohepatitis (NASH), a severe form of NAFLD, can progress to liver cirrhosis and hepatocellular carcinoma. NAFLD is regarded as a hepatic manifestation of metabolic syndrome and incidence has been increasing worldwide in line with the increased prevalence of obesity, type 2 diabetes, and hyperlipemia. Animal models of NAFLD/NASH give crucial information, not only in elucidating pathogenesis of NAFLD/NASH but also in examining therapeutic effects of various agents. An ideal model of NAFLD/NASH should correctly reflect both hepatic histopathology and pathophysiology of human NAFLD/NASH. Animal models of NAFLD/NASH are divided into genetic, dietary, and combination models. In this paper, we review commonly used animal models of NAFLD/NASH referring to their advantages and disadvantages.
Keywords: Animal model; Histopathology; Metabolic syndrome; Nonalcoholic fatty liver disease; Nonalcoholic steatohepatitis.
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References
-
- Angulo P. Nonalcoholic fatty liver disease. N Engl J Med. 2002;346:1221–1231. - PubMed
-
- Takahashi Y, Fukusato T. Pathology of nonalcoholic steatohepatitis. In: Current Research in Hepatology 2., editor. Trivandrum: Research Media; 2008. pp. 99–112.
-
- Powell EE, Cooksley WG, Hanson R, Searle J, Halliday JW, Powell LW. The natural history of nonalcoholic steatohepatitis: a follow-up study of forty-two patients for up to 21 years. Hepatology. 1990;11:74–80. - PubMed
-
- Harrison SA, Torgerson S, Hayashi PH. The natural history of nonalcoholic fatty liver disease: a clinical histopathological study. Am J Gastroenterol. 2003;98:2042–2047. - PubMed
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