Is BDNF biological link between depression and type 2 diabetes mellitus?
- PMID: 22626954
- DOI: 10.1016/j.mehy.2012.05.002
Is BDNF biological link between depression and type 2 diabetes mellitus?
Abstract
Epidemiological and clinical studies have demonstrated a strong association between depression and diabetes. Of note, depression is a risk factor for the development of type 2 diabetes mellitus (T2DM), while most patients with T2DM also have depression. Despite the abundance of evidence showing an epidemiological link between depression and T2DM, the cause of this association is still unknown. Brain-derived neurotrophic factor (BDNF) is widely expressed in the brain. Biological and clinical studies have repeatedly shown that BDNF is important in the pathogenesis of depression and T2DM. Therefore, we propose that BDNF may play an important role linking depression and T2DM. Studies examining the components of the BDNF system in patients with T2DM and depression may provide new understanding into the link between depression and T2DM. Such studies might also help us to identify potential treatment targets for these two common disorders.
Copyright © 2012 Elsevier Ltd. All rights reserved.
Similar articles
-
Chronic ethanol ingestion, type 2 diabetes mellitus, and brain-derived neurotrophic factor (BDNF) in rats.Neurosci Lett. 2011 Jan 7;487(2):149-52. doi: 10.1016/j.neulet.2010.10.011. Epub 2010 Oct 12. Neurosci Lett. 2011. PMID: 20946939
-
Serum brain-derived neurotrophic factor in patients with type 2 diabetes mellitus: Relationship to glucose metabolism and biomarkers of insulin resistance.Clin Biochem. 2008 Jul;41(10-11):812-7. doi: 10.1016/j.clinbiochem.2008.03.003. Epub 2008 Mar 19. Clin Biochem. 2008. PMID: 18402781
-
Self-reported hypoglycemia and impact on quality of life and depression among adults with type 2 diabetes mellitus.Diabetes Res Clin Pract. 2012 Jun;96(3):313-8. doi: 10.1016/j.diabres.2012.01.002. Epub 2012 Jan 31. Diabetes Res Clin Pract. 2012. PMID: 22296853
-
Brain-derived neurotrophic factor as a biomarker for mood disorders: an historical overview and future directions.Psychiatry Clin Neurosci. 2010 Aug;64(4):341-57. doi: 10.1111/j.1440-1819.2010.02113.x. Psychiatry Clin Neurosci. 2010. PMID: 20653908 Review.
-
Depression and type 2 diabetes: inflammatory mechanisms of a psychoneuroendocrine co-morbidity.Neurosci Biobehav Rev. 2012 Jan;36(1):658-76. doi: 10.1016/j.neubiorev.2011.10.001. Epub 2011 Oct 14. Neurosci Biobehav Rev. 2012. PMID: 22020230 Review.
Cited by
-
Serum brain-derived neurotrophic factor levels in type 2 diabetes mellitus patients and its association with cognitive impairment: A meta-analysis.PLoS One. 2024 Apr 22;19(4):e0297785. doi: 10.1371/journal.pone.0297785. eCollection 2024. PLoS One. 2024. PMID: 38648255 Free PMC article.
-
Depression with Comorbid Diabetes: What Evidence Exists for Treatments Using Traditional Chinese Medicine and Natural Products?Front Pharmacol. 2021 Jan 25;11:596362. doi: 10.3389/fphar.2020.596362. eCollection 2020. Front Pharmacol. 2021. PMID: 33568996 Free PMC article. Review.
-
Low-Molecular-Weight NGF Mimetic Corrects the Cognitive Deficit and Depression-like Behavior in Experimental Diabetes.Acta Naturae. 2017 Apr-Jun;9(2):94-102. Acta Naturae. 2017. PMID: 28740732 Free PMC article.
-
Geniposide alleviates depression-like behavior via enhancing BDNF expression in hippocampus of streptozotocin-evoked mice.Metab Brain Dis. 2016 Oct;31(5):1113-22. doi: 10.1007/s11011-016-9856-4. Epub 2016 Jun 16. Metab Brain Dis. 2016. PMID: 27311609
-
Brain-derived neurotrophic factor and its clinical implications.Arch Med Sci. 2015 Dec 10;11(6):1164-78. doi: 10.5114/aoms.2015.56342. Epub 2015 Dec 11. Arch Med Sci. 2015. PMID: 26788077 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
