Mammalian MAPK signal transduction pathways activated by stress and inflammation: a 10-year update
- PMID: 22535895
- DOI: 10.1152/physrev.00028.2011
Mammalian MAPK signal transduction pathways activated by stress and inflammation: a 10-year update
Abstract
The mammalian stress-activated families of mitogen-activated protein kinases (MAPKs) were first elucidated in 1994, and by 2001, substantial progress had been made in identifying the architecture of the pathways upstream of these kinases as well as in cataloguing candidate substrates. This information remains largely sound. Nevertheless, an informed understanding of the physiological and pathophysiological roles of these kinases remained to be accomplished. In the past decade, there has been an explosion of new work using RNAi in cells, as well as transgenic, knockout and conditional knockout technology in mice that has provided valuable insight into the functions of stress-activated MAPK pathways. These findings have important implications in our understanding of organ development, innate and acquired immunity, and diseases such as atherosclerosis, tumorigenesis, and type 2 diabetes. These new developments bring us within striking distance of the development and validation of novel treatment strategies. Herein we first summarize the molecular components of the mammalian stress-regulated MAPK pathways and their regulation as described thus far. We then review some of the in vivo functions of these pathways.
Similar articles
-
Scaffold proteins in mammalian MAP kinase cascades.J Biochem. 2004 Jun;135(6):657-61. doi: 10.1093/jb/mvh079. J Biochem. 2004. PMID: 15213240 Review.
-
bHLH-zip transcription factor Spz1 mediates mitogen-activated protein kinase cell proliferation, transformation, and tumorigenesis.Cancer Res. 2005 May 15;65(10):4041-50. doi: 10.1158/0008-5472.CAN-04-3658. Cancer Res. 2005. PMID: 15899793
-
Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation.Physiol Rev. 2001 Apr;81(2):807-69. doi: 10.1152/physrev.2001.81.2.807. Physiol Rev. 2001. PMID: 11274345 Review.
-
Emerging MAP kinase pathways in plant stress signalling.Trends Plant Sci. 2005 Jul;10(7):339-46. doi: 10.1016/j.tplants.2005.05.009. Trends Plant Sci. 2005. PMID: 15953753
-
Calcineurin-NFAT signaling regulates the cardiac hypertrophic response in coordination with the MAPKs.Cardiovasc Res. 2004 Aug 15;63(3):467-75. doi: 10.1016/j.cardiores.2004.01.021. Cardiovasc Res. 2004. PMID: 15276472 Review.
Cited by
-
Anti-inflammatory peptide therapeutics and the role of sulphur containing amino acids (cysteine and methionine) in inflammation suppression: A review.Inflamm Res. 2024 Jul;73(7):1203-1221. doi: 10.1007/s00011-024-01893-6. Epub 2024 May 21. Inflamm Res. 2024. PMID: 38769154 Review.
-
Research on the signaling pathway and the related mechanism of traditional Chinese medicine intervention in chronic gastritis of the "inflammation-cancer transformation".Front Pharmacol. 2024 Apr 18;15:1338471. doi: 10.3389/fphar.2024.1338471. eCollection 2024. Front Pharmacol. 2024. PMID: 38698812 Free PMC article. Review.
-
BMP2-ERK-ATF4 Axis-Based 6-methoxybenzofuran Compound I-9 Acts as Candidate Drug for Bone Formation and Anti-Osteoporosis.Int J Mol Sci. 2024 Mar 15;25(6):3350. doi: 10.3390/ijms25063350. Int J Mol Sci. 2024. PMID: 38542323 Free PMC article.
-
Anti-inflammatory potential via the MAPK signaling pathway of Lactobacillus spp. isolated from canine feces.PLoS One. 2024 Mar 27;19(3):e0299792. doi: 10.1371/journal.pone.0299792. eCollection 2024. PLoS One. 2024. PMID: 38536854 Free PMC article.
-
MAPK phosphatase 1 inhibition of p38α within lung myofibroblasts is essential for spontaneous fibrosis resolution.J Clin Invest. 2024 Mar 21;134(10):e172826. doi: 10.1172/JCI172826. J Clin Invest. 2024. PMID: 38512415 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous