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. 2012 Dec;66(12):1137-42.
doi: 10.1136/jech-2011-200114. Epub 2012 Apr 9.

Association of serum 25-hydroxyvitamin D₃ and D₂ with academic performance in childhood: findings from a prospective birth cohort

Anna-Maija Tolppanen  1 , Adrian Sayers, William D Fraser, Debbie A Lawlor
Affiliations
Free PMC article

Association of serum 25-hydroxyvitamin D₃ and D₂ with academic performance in childhood: findings from a prospective birth cohort

Anna-Maija Tolppanen et al. J Epidemiol Community Health. 2012 Dec.
Free PMC article

Abstract

Background: Higher total serum 25-hydroxyvitamin D (25(OH)D) concentrations have been associated with better cognitive function mainly in cross-sectional studies in adults. It is unknown if the associations of different forms of 25(OH)D (25(OH)D(3) and 25(OH)D(2)) are similar.

Methods: Prospective cohort study (n=3171) with serum 25(OH)D(3) and 25(OH)D(2) concentrations measured at mean age of 9.8 years and academic performance at age 13-14 years (total scores in English, mathematics and science) and 15-16 years (performance in General Certificates of Education examinations).

Results: Serum 25(OH)D(3) concentrations were not associated with any educational outcomes. Higher 25(OH)D(2) concentrations were associated with worse performance in English at age 13-14 years (adjusted SD change per doubling in 25(OH)D(2) (95% CI) -0.05 (-0.08 to -0.01)) and with worse academic performance at age 15-16 years (adjusted OR for obtaining ≥5 A*-C grades (95% CI) 0.91 (0.82 to 1.00)).

Conclusion: The null findings with 25(OH)D(3) are in line with two previous cross-sectional studies in children. It is possible that the positive association of 25(OH)D with cognitive function seen in adults does not emerge until later in life or that the results from previous cross-sectional adult studies are due to reverse causality. The unexpected inverse association of 25(OH)D(2) with academic performance requires replication in further studies. Taken together, our findings do not support suggestions that children should have controlled exposure to sunlight, or vitamin D supplements, in order to increase academic performance.

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Conflict of interest statement

Competing interests: None.

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References

    1. Whalley LJ, Deary IJ. Longitudinal cohort study of childhood IQ and survival up to age 76. BMJ 2001;322:819. - PMC - PubMed
    1. Hart CL, Taylor MD, Davey Smith G, et al. Childhood IQ, social class, deprivation, and their relationships with mortality and morbidity risk in later life: prospective observational study linking the Scottish Mental Survey 1932 and the Midspan studies. Psychosom Med 2003;65:877–83 - PubMed
    1. Osler M, Andersen AM, Due P, et al. Socioeconomic position in early life, birth weight, childhood cognitive function, and adult mortality. A longitudinal study of Danish men born in 1953. J Epidemiol Community Health 2003;57:681–6 - PMC - PubMed
    1. Osler M, Lawlor DA, Nordentoft M. Cognitive function in childhood and early adulthood and hospital admission for schizophrenia and bipolar disorders in Danish men born in 1953. Schizophr Res 2007;92:132–41 - PubMed
    1. Lawlor DA, Clark H, Leon DA. Associations between childhood intelligence and hospital admissions for unintentional injuries in adulthood: the Aberdeen children of the 1950s cohort study. Am J Public Health 2007;97:291–7 - PMC - PubMed

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