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. 2012 Feb 12;18(3):378-81.
doi: 10.1038/nm.2658.

RET, ROS1 and ALK fusions in lung cancer

Kengo Takeuchi  1 , Manabu Soda, Yuki Togashi, Ritsuro Suzuki, Seiji Sakata, Satoko Hatano, Reimi Asaka, Wakako Hamanaka, Hironori Ninomiya, Hirofumi Uehara, Young Lim Choi, Yukitoshi Satoh, Sakae Okumura, Ken Nakagawa, Hiroyuki Mano, Yuichi Ishikawa
Affiliations

RET, ROS1 and ALK fusions in lung cancer

Kengo Takeuchi et al. Nat Med. .

Abstract

Through an integrated molecular- and histopathology-based screening system, we performed a screening for fusions of anaplastic lymphoma kinase (ALK) and c-ros oncogene 1, receptor tyrosine kinase (ROS1) in 1,529 lung cancers and identified 44 ALK-fusion-positive and 13 ROS1-fusion-positive adenocarcinomas, including for unidentified fusion partners for ROS1. In addition, we discovered previously unidentified kinase fusions that may be promising for molecular-targeted therapy, kinesin family member 5B (KIF5B)-ret proto-oncogene (RET) and coiled-coil domain containing 6 (CCDC6)-RET, in 14 adenocarcinomas. A multivariate analysis of 1,116 adenocarcinomas containing these 71 kinase-fusion-positive adenocarcinomas identified four independent factors that are indicators of poor prognosis: age ≥ 50 years, male sex, high pathological stage and negative kinase-fusion status.

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Comment in

  • Genetics: Gene fusion power.
    Villanueva MT. Villanueva MT. Nat Rev Clin Oncol. 2012 Feb 28;9(4):188. doi: 10.1038/nrclinonc.2012.26. Nat Rev Clin Oncol. 2012. PMID: 22371133 No abstract available.
  • Chipping away at the lung cancer genome.
    Pao W, Hutchinson KE. Pao W, et al. Nat Med. 2012 Mar 6;18(3):349-51. doi: 10.1038/nm.2697. Nat Med. 2012. PMID: 22395697 No abstract available.

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