Down syndrome and hospitalizations due to respiratory syncytial virus: a population-based study
- PMID: 22177993
- DOI: 10.1016/j.jpeds.2011.11.004
Down syndrome and hospitalizations due to respiratory syncytial virus: a population-based study
Abstract
Objective: To assess the risk estimates for respiratory syncytial virus (RSV) hospitalization in children with Down syndrome (DS) and the clinical features and severity of RSV lower respiratory tract infection (LRTI) in hospitalized children.
Study design: Statewide hospitalization data for children with DS for 1995 through 2006 from the Colorado Health and Hospital Association database were combined with birth data from the Colorado Department of Public Health and Environment to obtain population-based estimates of RSV LRTI hospitalization for children with DS in the first 2 years of life. RSV hospitalization data for children with DS at the Children's Hospital Colorado for 2000 through 2006 were used to compare the course and severity of hospitalization of DS LRTI admissions with those of matched control subjects.
Results: There were 85 RSV LRTI hospitalizations in 630 children born with DS in Colorado, with 50 having no concurrent underlying conditions identified. Children with DS had a significantly higher risk than did those without DS for being hospitalized with RSV LRTI (OR, 5.99; 95% CI, 6.68-5.38), even in the absence of other underlying conditions (OR 3.5; 95% CI, 3.10-4.12). In the case-control study, children with DS hospitalized for RSV presented more frequently with fever (P = .005), had consolidation reported more often on chest radiography (P = .003), and were given bronchodilator therapy more often during the hospital stay (P = .002).
Conclusions: Children with DS have a higher risk of being hospitalized with RSV LRTI even in the absence of coexisting risk factors. They present more often with fever and more often have radiographic consolidation detected on chest radiography.
Copyright © 2012 Mosby, Inc. All rights reserved.
Similar articles
-
High incidence of recurrent wheeze in children with down syndrome with and without previous respiratory syncytial virus lower respiratory tract infection.Pediatr Infect Dis J. 2010 Jan;29(1):39-42. doi: 10.1097/INF.0b013e3181b34e52. Pediatr Infect Dis J. 2010. PMID: 19907362
-
Decline in respiratory syncytial virus hospitalizations in a region with high hospitalization rates and prolonged season.Pediatr Infect Dis J. 2006 Dec;25(12):1116-22. doi: 10.1097/01.inf.0000245104.26996.57. Pediatr Infect Dis J. 2006. PMID: 17133156
-
Respiratory syncytial virus-associated hospitalizations among infants and young children in the United States, 1997-2006.Pediatr Infect Dis J. 2012 Jan;31(1):5-9. doi: 10.1097/INF.0b013e31822e68e6. Pediatr Infect Dis J. 2012. PMID: 21817948
-
The epidemiology of respiratory syncytial virus (RSV) infections in South African children.S Afr Med J. 1999 Oct;89(10):1079-84. S Afr Med J. 1999. PMID: 10582064 Review.
-
Risk factors for respiratory syncytial virus associated with acute lower respiratory infection in children under five years: Systematic review and meta-analysis.J Glob Health. 2015 Dec;5(2):020416. doi: 10.7189/jogh.05.020416. J Glob Health. 2015. PMID: 26682048 Free PMC article. Review.
Cited by
-
Increased rate of respiratory symptoms in children with Down syndrome: a 2-year web-based parent-reported prospective study.Eur J Pediatr. 2022 Dec;181(12):4079-4089. doi: 10.1007/s00431-022-04634-1. Epub 2022 Oct 3. Eur J Pediatr. 2022. PMID: 36192547 Free PMC article.
-
The Burden of Respiratory Syncytial Virus in Children Under 2 Years of Age in a Rural Community in Maharashtra, India.Clin Infect Dis. 2021 Sep 2;73(Suppl_3):S238-S247. doi: 10.1093/cid/ciab508. Clin Infect Dis. 2021. PMID: 34472575 Free PMC article.
-
Respiratory Syncytial Virus-Associated Hospitalizations in Children With Neurological Disorders, 2006-2015.J Pediatric Infect Dis Soc. 2021 Nov 11;10(10):951-957. doi: 10.1093/jpids/piab017. J Pediatric Infect Dis Soc. 2021. PMID: 34245307 Free PMC article.
-
The impact of obstructive sleep apnea on bronchiolitis severity in children with Down syndrome.Sleep Med. 2021 Jul;83:188-195. doi: 10.1016/j.sleep.2021.04.004. Epub 2021 Apr 16. Sleep Med. 2021. PMID: 34022496 Free PMC article.
-
Respiratory Syncytial Virus-related Death in Children With Down Syndrome: The RSV GOLD Study.Pediatr Infect Dis J. 2020 Aug;39(8):665-670. doi: 10.1097/INF.0000000000002666. Pediatr Infect Dis J. 2020. PMID: 32332221 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical