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Review
. 2012 Oct;107(10):1726-34.
doi: 10.1111/j.1360-0443.2011.03546.x. Epub 2011 Oct 10.

Compulsive features in behavioural addictions: the case of pathological gambling

Nady el-Guebaly  1 , Tanya Mudry, Joseph Zohar, Hermano Tavares, Marc N Potenza
Affiliations
Review

Compulsive features in behavioural addictions: the case of pathological gambling

Nady el-Guebaly et al. Addiction. 2012 Oct.

Abstract

Aims: To describe, in the context of DSM-V, how a focus on addiction and compulsion is emerging in the consideration of pathological gambling (PG).

Methods: A systematic literature review of evidence for the proposed re-classification of PG as an addiction.

Results: Findings include: (i) phenomenological models of addiction highlighting a motivational shift from impulsivity to compulsivity associated with a protracted withdrawal syndrome and blurring of the ego-syntonic/ego-dystonic dichotomy; (ii) common neurotransmitter (dopamine, serotonin) contributions to PG and substance use disorders (SUDs); (iii) neuroimaging support for shared neurocircuitries between 'behavioural' and substance addictions and differences between obsessive-compulsive disorder (OCD), impulse control disorders (ICDs) and SUDs; (iv) genetic findings more closely related to endophenotypic constructs such as compulsivity and impulsivity than to psychiatric disorders; (v) psychological measures such as harm avoidance identifying a closer association between SUDs and PG than with OCD; (vi) community and pharmacotherapeutic trials data supporting a closer association between SUDs and PG than with OCD. Adapted behavioural therapies, such as exposure therapy, appear applicable to OCD, PG or SUDs, suggesting some commonalities across disorders.

Conclusions: PG shares more similarities with SUDs than with OCD. Similar to the investigation of impulsivity, studies of compulsivity hold promising insights concerning the course, differential diagnosis and treatment of PG, SUDs, and OCD.

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Conflict of interest statement

Declaration of Interest:

Dr. Nady el-Guebaly has no financial conflict of interest to report with respect to the content of this manuscript.

Tanya Mudry has no financial conflict of interest to report with respect to the content of this manuscript.

Dr. Zohar has received research funding and speaking fees from Lundbeck as well as research funding and consultancy fees from Servier.

Dr. Tavares has received research support from Cristalia, Roche, and Sandoz in his role as President of Brazil’s National Association on Pathological Gambling and Other Impulse Control Disorders.

Dr. Potenza has received research support from the Mohegan Sun Casino, the National Center for Responsible Gaming and its affiliated Institute for Research on Gambling Disorders (both gambling industry funded organisations); has consulted for and advised Boehringer Ingelheim; has consulted for and has financial interests in Somaxon; and Forest Laboratories, Ortho-McNeil, Oy-Control/Biotie, Glaxo-SmithKline and Psyadon pharmaceuticals.

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