Dopamine genes and reward dependence in adolescents with excessive internet video game play
- PMID: 21768948
- DOI: 10.1097/ADM.0b013e31811f465f
Dopamine genes and reward dependence in adolescents with excessive internet video game play
Abstract
Excessive internet video game play (EIGP) has emerged as a leading cause of behavioral and developmental problems in adolescents. Recent research has implicated the role of striatal dopaminergic system in the behavioral maladaptations associated with EIGP. This study investigates the reward-dependence characteristics in EIGP adolescents as it potentially relates to genetic polymorphisms of the dopaminergic system and temperament. Seventy-nine male EIGP adolescents and 75 age- and gender-matched healthy comparison adolescents were recruited. Associations were tested with respect to the reward-dependence (RD) scale in Cloninger's Temperament and Character Inventory and the frequencies of 3 dopamine polymorphisms: Taq1A1 allele of the dopamine D2 receptor (DRD2 Taq1A1) and Val158Met in the Catecholamine-O-Methyltransferase (COMT) genes. The Taq1A1 and low activity (COMT) alleles were significantly more prevalent in the EIGP group relative to the comparison group. The present EIGP group had significantly higher RD scores than controls. Within the EIGP group, the presence of the Taq1A1 allele correlated with higher RD scores. Our findings suggest that EIGP subjects have higher reward dependency and an increased prevalence of the DRD2 Taq1A1 and COMT alleles. In particular, the DRD2 Taq1A1 allele seems to be associated with reward dependence in EIGP adolescents.
Similar articles
-
Reduced dopamine receptor sensitivity as an intermediate phenotype in alcohol dependence and the role of the COMT Val158Met and DRD2 Taq1A genotypes.Arch Gen Psychiatry. 2012 Apr;69(4):339-48. doi: 10.1001/archgenpsychiatry.2011.1335. Arch Gen Psychiatry. 2012. PMID: 22474103
-
A preliminary study: novelty seeking, frontal executive function, and dopamine receptor (D2) TaqI A gene polymorphism in patients with methamphetamine dependence.Compr Psychiatry. 2008 Jul-Aug;49(4):387-92. doi: 10.1016/j.comppsych.2008.01.008. Epub 2008 Mar 21. Compr Psychiatry. 2008. PMID: 18555060
-
Depression like characteristics of 5HTTLPR polymorphism and temperament in excessive internet users.J Affect Disord. 2008 Jul;109(1-2):165-9. doi: 10.1016/j.jad.2007.10.020. Epub 2007 Nov 28. J Affect Disord. 2008. PMID: 18045695
-
Family-based and case-control study of DRD2, DAT, 5HTT, COMT genes polymorphisms in alcohol dependence.Neurosci Lett. 2006 Dec 13;410(1):1-5. doi: 10.1016/j.neulet.2006.05.005. Epub 2006 Oct 31. Neurosci Lett. 2006. PMID: 17079080
-
[Personality factors in depressive disorders: contribution of the psychobiologic model developed by Cloninger].Encephale. 2002 Jul-Aug;28(4):363-73. Encephale. 2002. PMID: 12232546 Review. French.
Cited by
-
Genetic Aspects of Problematic and Risky Internet Use in Young Men-Analysis of ANKK1, DRD2 and NTRK3 Gene Polymorphism.Genes (Basel). 2024 Jan 27;15(2):169. doi: 10.3390/genes15020169. Genes (Basel). 2024. PMID: 38397159 Free PMC article.
-
Neurobiological risk factors for problematic social media use as a specific form of Internet addiction: A narrative review.World J Psychiatry. 2023 May 19;13(5):160-173. doi: 10.5498/wjp.v13.i5.160. eCollection 2023 May 19. World J Psychiatry. 2023. PMID: 37303928 Free PMC article. Review.
-
A Bibliometric Analysis of Research into Internet Gaming Disorders in Korea.Int J Environ Res Public Health. 2023 Feb 21;20(5):3786. doi: 10.3390/ijerph20053786. Int J Environ Res Public Health. 2023. PMID: 36900797 Free PMC article. Review.
-
Molecular genetic associations between a prominent serotonin transporter gene polymorphism (5-HTTLPR/rs25531) and individual differences in tendencies toward autistic traits and generalized internet use disorder in China and Germany.Brain Behav. 2022 Oct;12(10):e2747. doi: 10.1002/brb3.2747. Epub 2022 Sep 15. Brain Behav. 2022. PMID: 36106519 Free PMC article.
-
Longer screen time utilization is associated with the polygenic risk for Attention-deficit/hyperactivity disorder with mediation by brain white matter microstructure.EBioMedicine. 2022 Jun;80:104039. doi: 10.1016/j.ebiom.2022.104039. Epub 2022 May 1. EBioMedicine. 2022. PMID: 35509143 Free PMC article.
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous