Twist2 contributes to breast cancer progression by promoting an epithelial-mesenchymal transition and cancer stem-like cell self-renewal
- PMID: 21602879
- DOI: 10.1038/onc.2011.181
Twist2 contributes to breast cancer progression by promoting an epithelial-mesenchymal transition and cancer stem-like cell self-renewal
Abstract
The epithelial to mesenchymal transition (EMT) is a highly conserved cellular programme that has an important role in normal embryogenesis and in cancer invasion and metastasis. We report here that Twist2, a tissue-specific basic helix-loop-helix transcription factor, is overexpressed in human breast cancers and lymph node metastases. In mammary epithelial cells and breast cancer cells, ectopic overexpression of Twist2 results in morphological transformation, downregulation of epithelial markers and upregulation of mesenchymal markers. Moreover, Twist2 enhances the cell migration and colony-forming abilities of mammary epithelial cells and breast cancer cells in vitro and promotes tumour growth in vivo. Ectopic expression of Twist2 in mammary epithelial cells and breast cancer cells increases the size and number of their CD44(high)/CD24(low) stem-like cell sub-populations, promotes the expression of stem cell markers and enhances the self-renewal capabilities of stem-like cells. In addition, exogenous expression of Twist2 leads to constitutive activation of STAT3 (signal transducer and activator of transcription 3) and downregulation of E-cadherin. Thus, the overexpression of Twist2 may contribute to breast cancer progression by activating the EMT programme and enhancing the self-renewal of cancer stem-like cells.
Similar articles
-
Twist2 promotes self-renewal of liver cancer stem-like cells by regulating CD24.Carcinogenesis. 2014 Mar;35(3):537-45. doi: 10.1093/carcin/bgt364. Epub 2013 Nov 5. Carcinogenesis. 2014. PMID: 24193512
-
HIF-2α promotes epithelial-mesenchymal transition through regulating Twist2 binding to the promoter of E-cadherin in pancreatic cancer.J Exp Clin Cancer Res. 2016 Feb 3;35:26. doi: 10.1186/s13046-016-0298-y. J Exp Clin Cancer Res. 2016. PMID: 26842802 Free PMC article.
-
RANK induces epithelial-mesenchymal transition and stemness in human mammary epithelial cells and promotes tumorigenesis and metastasis.Cancer Res. 2012 Jun 1;72(11):2879-88. doi: 10.1158/0008-5472.CAN-12-0044. Epub 2012 Apr 10. Cancer Res. 2012. PMID: 22496457
-
Direct activation of Bmi1 by Twist1: implications in cancer stemness, epithelial-mesenchymal transition, and clinical significance.Chang Gung Med J. 2011 May-Jun;34(3):229-38. Chang Gung Med J. 2011. PMID: 21733352 Review.
-
Linkage between Twist1 and Bmi1: molecular mechanism of cancer metastasis/stemness and clinical implications.Clin Exp Pharmacol Physiol. 2012 Aug;39(8):668-73. doi: 10.1111/j.1440-1681.2011.05594.x. Clin Exp Pharmacol Physiol. 2012. PMID: 21883379 Review.
Cited by
-
Uncovering hidden cancer self-dependencies through analysis of shRNA-level dependency scores.Sci Rep. 2024 Jan 9;14(1):856. doi: 10.1038/s41598-024-51453-5. Sci Rep. 2024. PMID: 38195844 Free PMC article.
-
Role of epithelial cell-mesenchymal transition regulators in molecular typing and prognosis of colon cancer.J Gastrointest Oncol. 2023 Apr 29;14(2):744-757. doi: 10.21037/jgo-23-49. Epub 2023 Apr 17. J Gastrointest Oncol. 2023. PMID: 37201067 Free PMC article.
-
Regulation of epithelial-mesenchymal transition by tumor microenvironmental signals and its implication in cancer therapeutics.Semin Cancer Biol. 2023 Jan;88:46-66. doi: 10.1016/j.semcancer.2022.12.002. Epub 2022 Dec 13. Semin Cancer Biol. 2023. PMID: 36521737 Free PMC article. Review.
-
Inhibition of NADPH Oxidase-ROS Signal using Hyaluronic Acid Nanoparticles for Overcoming Radioresistance in Cancer Therapy.ACS Nano. 2022 Nov 22;16(11):18708-18728. doi: 10.1021/acsnano.2c07440. Epub 2022 Oct 18. ACS Nano. 2022. PMID: 36256454 Free PMC article.
-
Immune Evasion of Hepatoma Cancer Stem-Like Cells from Natural Killer Cells.Ann Surg Oncol. 2022 Nov;29(12):7423-7433. doi: 10.1245/s10434-022-12220-w. Epub 2022 Jul 25. Ann Surg Oncol. 2022. PMID: 35876924
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Miscellaneous