The paradox of α-adrenergic coronary vasoconstriction revisited
- PMID: 21458461
- DOI: 10.1016/j.yjmcc.2011.03.007
The paradox of α-adrenergic coronary vasoconstriction revisited
Abstract
Activation of coronary vascular α-adrenoceptors results in vasoconstriction which competes with metabolic vasodilation during sympathetic activation. Epicardial conduit vessel constriction is largely mediated by α(1)-adrenoceptors; the constriction of the resistive microcirculation largely by α(2)-adrenoceptors, but also by α(1)-adrenoceptors. There is no firm evidence that α-adrenergic coronary vasoconstriction exerts a beneficial effect on transmural blood flow distribution. In fact, α-blockade in anesthetized and conscious dogs improves blood flow to all transmural layers, during normoperfusion and hypoperfusion. Also, in patients with coronary artery disease, blockade of α(1)- and α(2)-adrenoceptors improves coronary blood flow, myocardial function and metabolism.
Copyright © 2011 Elsevier Ltd. All rights reserved.
Republished in
-
Reprint of: the paradox of α-adrenergic coronary vasoconstriction revisited.J Mol Cell Cardiol. 2012 Apr;52(4):832-9. doi: 10.1016/j.yjmcc.2011.12.010. J Mol Cell Cardiol. 2012. PMID: 22420694
Similar articles
-
Reprint of: the paradox of α-adrenergic coronary vasoconstriction revisited.J Mol Cell Cardiol. 2012 Apr;52(4):832-9. doi: 10.1016/j.yjmcc.2011.12.010. J Mol Cell Cardiol. 2012. PMID: 22420694
-
[Significance of the sympathetic nervous system for the coronary circulation].Z Kardiol. 1984 Sep;73(9):543-51. Z Kardiol. 1984. PMID: 6506839 German.
-
[Coronary vasomotion in myocardial ischemia].Z Kardiol. 1989 Aug;78(8):485-99. Z Kardiol. 1989. PMID: 2678793 Review. German.
-
The sympathetic nervous system and ischaemic heart disease.Eur Heart J. 1998 Jun;19 Suppl F:F62-71. Eur Heart J. 1998. PMID: 9651738 Review.
-
[Alpha-adrenergic control of coronary circulation and left ventricular function during exertion].Verh K Acad Geneeskd Belg. 1990;52(3):225-91. Verh K Acad Geneeskd Belg. 1990. PMID: 1977244 Dutch.
Cited by
-
Heartbeats and high scores: esports triggers cardiovascular and autonomic stress response.Front Sports Act Living. 2024 Apr 4;6:1380903. doi: 10.3389/fspor.2024.1380903. eCollection 2024. Front Sports Act Living. 2024. PMID: 38638448 Free PMC article.
-
Novel Arylpiperazine Derivatives of Salicylamide with α1-Adrenolytic Properties Showed Antiarrhythmic and Hypotensive Properties in Rats.Int J Mol Sci. 2022 Dec 24;24(1):293. doi: 10.3390/ijms24010293. Int J Mol Sci. 2022. PMID: 36613736 Free PMC article.
-
Mental Stress and Cardiovascular Health-Part I.J Clin Med. 2022 Jun 10;11(12):3353. doi: 10.3390/jcm11123353. J Clin Med. 2022. PMID: 35743423 Free PMC article. Review.
-
Heart rate dynamics in the prediction of coronary artery disease and myocardial infarction using artificial neural network and support vector machine.J Appl Biomed. 2022 Jun;20(2):70-79. doi: 10.32725/jab.2022.008. Epub 2022 Jun 21. J Appl Biomed. 2022. PMID: 35727124
-
A pathophysiological compass to personalize antianginal drug treatment.Nat Rev Cardiol. 2021 Dec;18(12):838-852. doi: 10.1038/s41569-021-00573-w. Epub 2021 Jul 7. Nat Rev Cardiol. 2021. PMID: 34234310 Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
