Effects of Hericium erinaceus on amyloid β(25-35) peptide-induced learning and memory deficits in mice
- PMID: 21383512
- DOI: 10.2220/biomedres.32.67
Effects of Hericium erinaceus on amyloid β(25-35) peptide-induced learning and memory deficits in mice
Abstract
The mushroom Hericium erinaceus has been used as a food and herbal medicine since ancient times in East Asia. It has been reported that H. erinaceus promotes nerve growth factor secretion in vitro and in vivo. Nerve growth factor is involved in maintaining and organizing cholinergic neurons in the central nervous system. These findings suggest that H. erinaceus may be appropriate for the prevention or treatment of dementia. In the present study, we examined the effects of H. erinaceus on amyloid β(25-35) peptide-induced learning and memory deficits in mice. Mice were administered 10 µg of amyloid β(25-35) peptide intracerebroventricularly on days 7 and 14, and fed a diet containing H. erinaceus over a 23-d experimental period. Memory and learning function was examined using behavioral pharmacological methods including the Y-maze test and the novel-object recognition test. The results revealed that H. erinaceus prevented impairments of spatial short-term and visual recognition memory induced by amyloid β(25-35) peptide. This finding indicates that H. erinaceus may be useful in the prevention of cognitive dysfunction.
Similar articles
-
Neurotrophic and Neuroprotective Effects of Hericium erinaceus.Int J Mol Sci. 2023 Nov 3;24(21):15960. doi: 10.3390/ijms242115960. Int J Mol Sci. 2023. PMID: 37958943 Free PMC article. Review.
-
Dietary Supplementation of Lion's Mane Medicinal Mushroom, Hericium erinaceus (Agaricomycetes), and Spatial Memory in Wild-Type Mice.Int J Med Mushrooms. 2018;20(5):485-494. doi: 10.1615/IntJMedMushrooms.2018026241. Int J Med Mushrooms. 2018. PMID: 29953363
-
Xanthoceraside attenuates amyloid β peptide₂₅₋₃₅-induced learning and memory impairments in mice.Psychopharmacology (Berl). 2012 Jan;219(1):181-90. doi: 10.1007/s00213-011-2386-1. Epub 2011 Jul 7. Psychopharmacology (Berl). 2012. PMID: 21735075
-
Systemic Screening of Strains of the Lion's Mane Medicinal Mushroom Hericium erinaceus (Higher Basidiomycetes) and Its Protective Effects on Aβ-Triggered Neurotoxicity in PC12 Cells.Int J Med Mushrooms. 2015;17(3):219-29. doi: 10.1615/intjmedmushrooms.v17.i3.20. Int J Med Mushrooms. 2015. PMID: 25954906
-
The Monkey Head Mushroom and Memory Enhancement in Alzheimer's Disease.Cells. 2022 Jul 24;11(15):2284. doi: 10.3390/cells11152284. Cells. 2022. PMID: 35892581 Free PMC article. Review.
Cited by
-
The Acute and Chronic Effects of Lion's Mane Mushroom Supplementation on Cognitive Function, Stress and Mood in Young Adults: A Double-Blind, Parallel Groups, Pilot Study.Nutrients. 2023 Nov 20;15(22):4842. doi: 10.3390/nu15224842. Nutrients. 2023. PMID: 38004235 Free PMC article. Clinical Trial.
-
Neurotrophic and Neuroprotective Effects of Hericium erinaceus.Int J Mol Sci. 2023 Nov 3;24(21):15960. doi: 10.3390/ijms242115960. Int J Mol Sci. 2023. PMID: 37958943 Free PMC article. Review.
-
Comprehensive Review of Nutraceuticals against Cognitive Decline Associated with Alzheimer's Disease.ACS Omega. 2023 Sep 20;8(39):35499-35522. doi: 10.1021/acsomega.3c04855. eCollection 2023 Oct 3. ACS Omega. 2023. PMID: 37810693 Free PMC article. Review.
-
Bioactive Peptides from Edible Mushrooms-The Preparation, Mechanisms, Structure-Activity Relationships and Prospects.Foods. 2023 Aug 2;12(15):2935. doi: 10.3390/foods12152935. Foods. 2023. PMID: 37569204 Free PMC article. Review.
-
Hericium erinaceus in Neurodegenerative Diseases: From Bench to Bedside and Beyond, How Far from the Shoreline?J Fungi (Basel). 2023 May 10;9(5):551. doi: 10.3390/jof9050551. J Fungi (Basel). 2023. PMID: 37233262 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical