Review
doi: 10.1038/348125a0.
The GTPase superfamily: a conserved switch for diverse cell functions
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- PMID: 2122258
- DOI: 10.1038/348125a0
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Review
The GTPase superfamily: a conserved switch for diverse cell functions
Nature.
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Abstract
Proteins that bind and hydrolyse GTP are being discovered at a rapidly increasing rate. Each of these many GTPases acts as a molecular switch whose 'on' and 'off' states are triggered by binding and hydrolysis of GTP. Conserved structure and mechanism in myriad versions of the switch--in bacteria, yeast, flies and vertebrates--suggest that all derive from a single primordial protein, repeatedly modified in the course of evolution to perform a dazzling variety of functions.
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