NUTRIOSE dietary fiber supplementation improves insulin resistance and determinants of metabolic syndrome in overweight men: a double-blind, randomized, placebo-controlled study
- PMID: 21164548
- DOI: 10.1139/H10-074
NUTRIOSE dietary fiber supplementation improves insulin resistance and determinants of metabolic syndrome in overweight men: a double-blind, randomized, placebo-controlled study
Abstract
The influence of dietary fiber on determinants of metabolic syndrome is controversial. The objective of this study was to determine the effects of NUTRIOSE supplementation on insulin resistance and the determinants of metabolic syndrome in overweight men. In this double-blind, randomized, placebo-controlled study, we supplemented the diets of overweight Chinese men with 250 mL of fruit juice that contained NUTRIOSE (Test group: n = 60, age = 30.4 ± 4.3 years, body mass index (BMI) = 24.5 ± 0.2 kg·m-2) or a maltodextrin placebo (
Control group: n = 60, age = 31.6 ± 4.1 years, BMI = 24.5 ± 0.3 kg·m-2) at a dosage of 17 g twice daily for 12 weeks. Daily caloric intake, body composition, blood chemistry, and blood pressure were evaluated every 4 weeks during the trial. Test subjects consumed fewer calories per day and had greater reductions in body weight, BMI, body fat percentage, and waist circumference than Control subjects. All markers of glucose metabolism improved in the Test group, with increases in adiponectin and reductions in glucose, insulin, homeostasis model assessment-estimated insulin resistance, glycosylated hemoglobin, and glycated albumin (all p < 0.01). Similarly, all lipid measures improved with increases in high-density lipoprotein cholesterol and reductions in total cholesterol, low-density lipoprotein cholesterol, very low-density lipoprotein cholesterol, and triglycerides (all p < 0.01). No changes were observed in systolic blood pressure between groups. Most components of glucose metabolism and the lipid profile were significantly better in the Test than in the Control subjects. No adverse events or gastrointestinal complaints were reported in either group. Supplementation with NUTRIOSE for 12 weeks is well tolerated, lowers insulin resistance, and improves determinants of metabolic syndrome in overweight men.
Trial registration: ClinicalTrials.gov NCT01044680.
Similar articles
-
Calcium plus vitamin D supplementation affects glucose metabolism and lipid concentrations in overweight and obese vitamin D deficient women with polycystic ovary syndrome.Clin Nutr. 2015 Aug;34(4):586-92. doi: 10.1016/j.clnu.2014.09.015. Epub 2014 Oct 3. Clin Nutr. 2015. PMID: 25300649 Clinical Trial.
-
Whole-grain ready-to-eat oat cereal, as part of a dietary program for weight loss, reduces low-density lipoprotein cholesterol in adults with overweight and obesity more than a dietary program including low-fiber control foods.J Am Diet Assoc. 2010 Feb;110(2):205-14. doi: 10.1016/j.jada.2009.10.037. J Am Diet Assoc. 2010. PMID: 20102847 Clinical Trial.
-
Effects of omega-3 fatty acids supplementation on serum adiponectin levels and some metabolic risk factors in women with polycystic ovary syndrome.Asia Pac J Clin Nutr. 2012;21(4):511-8. Asia Pac J Clin Nutr. 2012. PMID: 23017309 Clinical Trial.
-
Effects of isolated soluble fiber supplementation on body weight, glycemia, and insulinemia in adults with overweight and obesity: a systematic review and meta-analysis of randomized controlled trials.Am J Clin Nutr. 2017 Dec;106(6):1514-1528. doi: 10.3945/ajcn.117.163246. Epub 2017 Nov 1. Am J Clin Nutr. 2017. PMID: 29092878 Review.
-
Effects of tea or tea extract on metabolic profiles in patients with type 2 diabetes mellitus: a meta-analysis of ten randomized controlled trials.Diabetes Metab Res Rev. 2016 Jan;32(1):2-10. doi: 10.1002/dmrr.2641. Epub 2015 Apr 21. Diabetes Metab Res Rev. 2016. PMID: 25689396 Review.
Cited by
-
Dichotomous effect of dietary fiber in pediatrics: a narrative review of the health benefits and tolerance of fiber.Eur J Clin Nutr. 2024 Jul;78(7):557-568. doi: 10.1038/s41430-024-01429-5. Epub 2024 Mar 13. Eur J Clin Nutr. 2024. PMID: 38480843 Review.
-
Pathophysiological-Based Nutritional Interventions in Cirrhotic Patients with Sarcopenic Obesity: A State-of-the-Art Narrative Review.Nutrients. 2024 Jan 31;16(3):427. doi: 10.3390/nu16030427. Nutrients. 2024. PMID: 38337711 Free PMC article. Review.
-
Effects of Soluble Dietary Fibre on Exercise Performance and Perception of Fatigue in Young Basketball Players.Food Technol Biotechnol. 2023 Sep;61(3):389-401. doi: 10.17113/ftb.61.03.23.8124. Food Technol Biotechnol. 2023. PMID: 38022878 Free PMC article.
-
Soluble Fiber Effect on Human Serum Leptin and Adiponectin: A Systematic Review and Dose-Response Meta-Analysis.Clin Nutr Res. 2023 Oct 30;12(4):320-335. doi: 10.7762/cnr.2023.12.4.320. eCollection 2023 Oct. Clin Nutr Res. 2023. PMID: 37969941 Free PMC article.
-
Dietary carbohydrate quality index (CQI), cardio-metabolic risk factors and insulin resistance among adults with obesity.BMC Endocr Disord. 2023 Aug 11;23(1):171. doi: 10.1186/s12902-023-01420-4. BMC Endocr Disord. 2023. PMID: 37568117 Free PMC article.
Publication types
MeSH terms
Substances
Associated data
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical