Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2011 Jan;43(1):55-9.
doi: 10.1038/ng.732. Epub 2010 Dec 12.

Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3

Zi-Jiang Chen  1 , Han Zhao, Lin He, Yuhua Shi, Yingying Qin, Yongyong Shi, Zhiqiang Li, Li You, Junli Zhao, Jiayin Liu, Xiaoyan Liang, Xiaoming Zhao, Junzhao Zhao, Yingpu Sun, Bo Zhang, Hong Jiang, Dongni Zhao, Yuehong Bian, Xuan Gao, Ling Geng, Yiran Li, Dongyi Zhu, Xiuqin Sun, Jin-E Xu, Cuifang Hao, Chun-E Ren, Yajie Zhang, Shiling Chen, Wei Zhang, Aijun Yang, Junhao Yan, Yuan Li, Jinlong Ma, Yueran Zhao
Affiliations

Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3

Zi-Jiang Chen et al. Nat Genet. 2011 Jan.

Abstract

Polycystic ovary syndrome (PCOS) is a common metabolic disorder in women. To identify causative genes, we conducted a genome-wide association study (GWAS) of PCOS in Han Chinese. The discovery set included 744 PCOS cases and 895 controls; subsequent replications involved two independent cohorts (2,840 PCOS cases and 5,012 controls from northern Han Chinese; 498 cases and 780 controls from southern and central Han Chinese). We identified strong evidence of associations between PCOS and three loci: 2p16.3 (rs13405728; combined P-value by meta-analysis P(meta) = 7.55 × 10⁻²¹, odds ratio (OR) 0.71); 2p21 (rs13429458, P(meta) = 1.73 × 10⁻²³, OR 0.67); and 9q33.3 (rs2479106, P(meta) = 8.12 × 10⁻¹⁹, OR 1.34). These findings provide new insight into the pathogenesis of PCOS. Follow-up studies of the candidate genes in these regions are recommended.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Mol Hum Reprod. 2002 Oct;8(10):893-9 - PubMed
    1. Horm Metab Res. 2001 Apr;33(4):221-6 - PubMed
    1. Fertil Steril. 2004 Jan;81(1):19-25 - PubMed
    1. J Clin Endocrinol Metab. 2000 Dec;85(12):4426-33 - PubMed
    1. Zhonghua Fu Chan Ke Za Zhi. 2004 Sep;39(9):582-5 - PubMed

Publication types

LinkOut - more resources