Epigenetic epidemiology of common complex disease: prospects for prediction, prevention, and treatment
- PMID: 21048988
- PMCID: PMC2964338
- DOI: 10.1371/journal.pmed.1000356
Epigenetic epidemiology of common complex disease: prospects for prediction, prevention, and treatment
Abstract
As part of the PLoS Epigenetics Collection, Caroline Relton and George Davey Smith discuss the potential of epigenetics for the treatment and prevention of common complex diseases, including cancer.
Conflict of interest statement
The authors have declared that no competing interests exist.
Figures
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References
-
- Feero WG, Guttmacher AE, Collins FS. Genomic medicine–An updated primer. New Engl J Med. 2010;362:2001–2011. - PubMed
-
- Bird A. Perceptions of epigenetics. Nature. 2007;447:396–398. - PubMed
-
- Vaissiere T, Sawan C, Herceg Z. Epigenetic interplay between histone modifications and DNA methylation in gene silencing. Mutat Res. 2008;659:40–48. - PubMed
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