Associations between physical fitness and HbA₁(c) in type 2 diabetes mellitus
- PMID: 20953579
- DOI: 10.1007/s00125-010-1941-3
Associations between physical fitness and HbA₁(c) in type 2 diabetes mellitus
Abstract
Aim/hypothesis: In people with type 2 diabetes, exercise improves glucose control (as reflected in HbA₁(c)) and physical fitness, but it is not clear to what extent these exercise-induced improvements are correlated with one another. We hypothesised that reductions in HbA₁(c) would be related: (1) to increases in aerobic fitness and strength respectively in patients performing aerobic training or resistance training; and (2) to changes in strength and aerobic fitness in patients performing aerobic and resistance training.
Methods: We randomly allocated 251 type 2 diabetes patients to aerobic, resistance, or aerobic plus resistance training, or to a sedentary control group. Peak oxygen consumption VO₂(peak), workload, treadmill time and ventilatory threshold measurements from maximal treadmill exercise testing were measured at baseline and 6 months. Muscular strength was measured as the maximum weight that could be lifted eight times on the leg press, bench press and seated row exercises.
Results: With aerobic training, significant associations were found between changes in both VO₂(peak) (p = 0.040) and workload (p = 0.022), and changes in HbA₁(c.) With combined training, improvements in VO₂(peak) (p = 0.008), workload (p = 0.034) and ventilatory threshold (p = 0.003) were significantly associated with changes in HbA₁(c.) Increases in strength on the seated row (p = 0.006) and in mid-thigh muscle cross-sectional area (p = 0.030) were significantly associated with changes in HbA₁(c) after resistance exercise, whereas the association between increases in muscle cross-sectional area and HbA₁(c) in participants doing aerobic plus resistance exercise (p = 0.059) was of borderline significance.
Conclusions/interpretation: There appears to be a link between changes in fitness and HbA₁(c). The improvements in cardiorespiratory fitness with aerobic training may be a better predictor of changes in HbA₁(c) than improvements in strength.
Similar articles
-
Changes in physical fitness predict improvements in modifiable cardiovascular risk factors independently of body weight loss in subjects with type 2 diabetes participating in the Italian Diabetes and Exercise Study (IDES).Diabetes Care. 2012 Jun;35(6):1347-54. doi: 10.2337/dc11-1859. Epub 2012 Mar 7. Diabetes Care. 2012. PMID: 22399699 Free PMC article. Clinical Trial.
-
Metabolic effects of aerobic training and resistance training in type 2 diabetic subjects: a randomized controlled trial (the RAED2 study).Diabetes Care. 2012 Apr;35(4):676-82. doi: 10.2337/dc11-1655. Epub 2012 Feb 16. Diabetes Care. 2012. PMID: 22344613 Free PMC article. Clinical Trial.
-
Physical activity advice only or structured exercise training and association with HbA1c levels in type 2 diabetes: a systematic review and meta-analysis.JAMA. 2011 May 4;305(17):1790-9. doi: 10.1001/jama.2011.576. JAMA. 2011. PMID: 21540423 Review.
-
Effect of exercise training on physical fitness in type II diabetes mellitus.Med Sci Sports Exerc. 2010 Aug;42(8):1439-47. doi: 10.1249/MSS.0b013e3181d322dd. Med Sci Sports Exerc. 2010. PMID: 20639722 Clinical Trial.
-
Physical activity/exercise training in type 2 diabetes. The role of the Italian Diabetes and Exercise Study.Diabetes Metab Res Rev. 2009 Sep;25 Suppl 1:S29-33. doi: 10.1002/dmrr.985. Diabetes Metab Res Rev. 2009. PMID: 19662617 Review.
Cited by
-
Exercise Prescription for Postprandial Glycemic Management.Nutrients. 2024 Apr 14;16(8):1170. doi: 10.3390/nu16081170. Nutrients. 2024. PMID: 38674861 Free PMC article. Review.
-
Effects of exercise training parameters on cardiorespiratory fitness of individuals with type 2 diabetes mellitus: a systematic review and meta-analysis.J Diabetes Metab Disord. 2023 Mar 31;22(1):97-118. doi: 10.1007/s40200-023-01205-5. eCollection 2023 Jun. J Diabetes Metab Disord. 2023. PMID: 37255785 Free PMC article. Review.
-
Intensity Differences of Resistance Training for Type 2 Diabetic Patients: A Systematic Review and Meta-Analysis.Healthcare (Basel). 2023 Feb 3;11(3):440. doi: 10.3390/healthcare11030440. Healthcare (Basel). 2023. PMID: 36767015 Free PMC article. Review.
-
Association between haemoglobin A1c and whole-body heat loss during exercise-heat stress in physically active men with type 2 diabetes.Exp Physiol. 2023 Mar;108(3):338-343. doi: 10.1113/EP090915. Epub 2023 Feb 1. Exp Physiol. 2023. PMID: 36724895 Free PMC article.
-
The Effects of Exercise Habit on Albuminuria and Metabolic Indices in Patients with Type 2 Diabetes Mellitus: A Cross-Sectional Study.Medicina (Kaunas). 2022 Apr 23;58(5):577. doi: 10.3390/medicina58050577. Medicina (Kaunas). 2022. PMID: 35629994 Free PMC article.
References
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Medical
Miscellaneous