Gastrointestinal microbiota in irritable bowel syndrome: present state and perspectives
- PMID: 20705664
- DOI: 10.1099/mic.0.043257-0
Gastrointestinal microbiota in irritable bowel syndrome: present state and perspectives
Abstract
Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder that has been associated with aberrant microbiota. This review focuses on the recent molecular insights generated by analysing the intestinal microbiota in subjects suffering from IBS. Special emphasis is given to studies that compare and contrast the microbiota of healthy subjects with that of IBS patients classified into different subgroups based on their predominant bowel pattern as defined by the Rome criteria. The current data available from a limited number of patients do not reveal pronounced and reproducible IBS-related deviations of entire phylogenetic or functional microbial groups, but rather support the concept that IBS patients have alterations in the proportions of commensals with interrelated changes in the metabolic output and overall microbial ecology. The lack of apparent similarities in the taxonomy of microbiota in IBS patients may partially arise from the fact that the applied molecular methods, the nature and location of IBS subjects, and the statistical power of the studies have varied considerably. Most recent advances, especially the finding that several uncharacterized phylotypes show non-random segregation between healthy and IBS subjects, indicate the possibility of discovering bacteria specific for IBS. Moreover, tools are being developed for the functional analysis of the relationship between the intestinal microbiota and IBS. These approaches may be instrumental in the evaluation of the ecological dysbiosis hypothesis in the gut ecosystem. Finally, we discuss the future outlook for research avenues and candidate microbial biomarkers that may eventually be used in IBS diagnosis.
Similar articles
-
Functional dysbiosis within the gut microbiota of patients with constipated-irritable bowel syndrome.Aliment Pharmacol Ther. 2012 Apr;35(7):828-38. doi: 10.1111/j.1365-2036.2012.05007.x. Epub 2012 Feb 8. Aliment Pharmacol Ther. 2012. PMID: 22315951
-
Microbial community analysis reveals high level phylogenetic alterations in the overall gastrointestinal microbiota of diarrhoea-predominant irritable bowel syndrome sufferers.BMC Gastroenterol. 2009 Dec 17;9:95. doi: 10.1186/1471-230X-9-95. BMC Gastroenterol. 2009. PMID: 20015409 Free PMC article.
-
Composition and temporal stability of gastrointestinal microbiota in irritable bowel syndrome--a longitudinal study in IBS and control subjects.FEMS Immunol Med Microbiol. 2005 Feb 1;43(2):213-22. doi: 10.1016/j.femsim.2004.08.009. FEMS Immunol Med Microbiol. 2005. PMID: 15747442
-
Intestinal microbiota and its role in irritable bowel syndrome (IBS).Curr Gastroenterol Rep. 2013 May;15(5):323. doi: 10.1007/s11894-013-0323-7. Curr Gastroenterol Rep. 2013. PMID: 23580243 Review.
-
Microbiota in health and irritable bowel syndrome: current knowledge, perspectives and therapeutic options.Scand J Gastroenterol. 2013 Sep;48(9):995-1009. doi: 10.3109/00365521.2013.799220. Scand J Gastroenterol. 2013. PMID: 23964766 Review.
Cited by
-
Unraveling the Microbiome-Human Body Axis: A Comprehensive Examination of Therapeutic Strategies, Interactions and Implications.Int J Mol Sci. 2024 May 20;25(10):5561. doi: 10.3390/ijms25105561. Int J Mol Sci. 2024. PMID: 38791599 Free PMC article. Review.
-
Impact of bread diet on intestinal dysbiosis and irritable bowel syndrome symptoms in quiescent ulcerative colitis: A pilot study.PLoS One. 2024 Feb 16;19(2):e0297836. doi: 10.1371/journal.pone.0297836. eCollection 2024. PLoS One. 2024. PMID: 38363772 Free PMC article. Clinical Trial.
-
From-Toilet-to-Freezer: A Review on Requirements for an Automatic Protocol to Collect and Store Human Fecal Samples for Research Purposes.Biomedicines. 2023 Sep 28;11(10):2658. doi: 10.3390/biomedicines11102658. Biomedicines. 2023. PMID: 37893032 Free PMC article. Review.
-
Fecal Microbiota Transplantation in Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Int J Mol Sci. 2023 Sep 26;24(19):14562. doi: 10.3390/ijms241914562. Int J Mol Sci. 2023. PMID: 37834010 Free PMC article. Review.
-
Efficacy and safety of human gut-derived multi-strain probiotics in patients with irritable bowel syndrome: A prospective open-label observation study.Medicine (Baltimore). 2023 Aug 25;102(34):e34899. doi: 10.1097/MD.0000000000034899. Medicine (Baltimore). 2023. PMID: 37653742 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical