Henoch-Schölein purpura and polysaccharide meningococcal vaccine
- PMID: 20624811
- DOI: 10.1542/peds.2009-3195
Henoch-Schölein purpura and polysaccharide meningococcal vaccine
Abstract
Background: We describe here a case of Henoch-Schönlein purpura (HSP) that occurred 10 days after administration of the meningococcal polysaccharide vaccine and came to the attention of a Vaccine Safety Datalink (VSD) investigator (but did not occur in the VSD cohort). Periodic case reports have linked vaccines to HSP.
Objective: To better understand the potential risk for HSP after immunization with the meningococcal polysaccharide vaccine.
Patients and methods: We studied the VSD cohort to estimate the 42-day postvaccination incidence rate of HSP in the VSD population 16 to 20 years of age. Electronic data from all 8 VSD sites were gathered. All subjects aged 16 to 20 years who received a meningococcal polysaccharide vaccine were followed for 42 days after that vaccination for evidence of HSP. Background rates were determined by examining all the nonexposed time of the same cohort.
Results: No cases of HSP were seen in the 42 days after 49,027 doses of meningococcal polysaccharide vaccine among the entire VSD adolescent and young adult population. The background incidence rate was 4.2 per 100,000 person-years.
Conclusion: These data provide the strongest evidence so far that HSP is not associated with receipt of meningococcal polysaccharide vaccine in the 16- to 20-year age group.
Similar articles
-
Henoch-Schönlein purpura and meningococcal B vaccination.Arch Dis Child. 2009 Mar;94(3):224-6. doi: 10.1136/adc.2007.125195. Epub 2008 Jul 23. Arch Dis Child. 2009. PMID: 18650242
-
Recurrent Henoch-Schönlein purpura in children.J Clin Rheumatol. 2007 Feb;13(1):25-8. doi: 10.1097/01.rhu.0000255692.46165.19. J Clin Rheumatol. 2007. PMID: 17278945
-
Prevention of meningococcal disease.Am Fam Physician. 2005 Nov 15;72(10):2049-56. Am Fam Physician. 2005. PMID: 16342836 Review.
-
Meningococcal disease in catalonia 1 year after mass vaccination campaign with meningococcal group C polysaccharide vaccine.Infection. 2003 Dec;31(6):392-7. doi: 10.1007/s15010-003-3121-6. Infection. 2003. PMID: 14735381
-
Henoch-Schonlein purpura following a meningococcal vaccine.Pediatrics. 2003 Dec;112(6 Pt 1):e491. doi: 10.1542/peds.112.6.e491. Pediatrics. 2003. PMID: 14654652
Cited by
-
Cutaneous Manifestations of Small-Vessel Leukocytoclastic Vasculitides in Childhood.Clin Rev Allergy Immunol. 2017 Dec;53(3):439-451. doi: 10.1007/s12016-017-8626-3. Clin Rev Allergy Immunol. 2017. PMID: 28836099 Review.
-
Henoch-Schönlein purpura and drug and vaccine use in childhood: a case-control study.Ital J Pediatr. 2016 Jun 18;42(1):60. doi: 10.1186/s13052-016-0267-2. Ital J Pediatr. 2016. PMID: 27316345 Free PMC article.
-
Vaccines, adjuvants and autoimmunity.Pharmacol Res. 2015 Oct;100:190-209. doi: 10.1016/j.phrs.2015.08.003. Epub 2015 Aug 12. Pharmacol Res. 2015. PMID: 26275795 Free PMC article. Review.
-
Autoimmune/inflammatory syndrome induced by adjuvants (ASIA): clues and pitfalls in the pediatric background.Immunol Res. 2014 Dec;60(2-3):366-75. doi: 10.1007/s12026-014-8586-0. Immunol Res. 2014. PMID: 25395340 Review.
-
The Vaccine Safety Datalink: successes and challenges monitoring vaccine safety.Vaccine. 2014 Sep 22;32(42):5390-8. doi: 10.1016/j.vaccine.2014.07.073. Epub 2014 Aug 6. Vaccine. 2014. PMID: 25108215 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources