Comment
doi: 10.1038/jid.2009.370.
More or less: copy number alterations in mycosis fungoides
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- PMID: 20231832
- DOI: 10.1038/jid.2009.370
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Comment
More or less: copy number alterations in mycosis fungoides
J Invest Dermatol.
2010 Apr.
Free article
Abstract
Mycosis fungoides (MF) is the most common form of cutaneous T-cell lymphoma (CTCL), a heterogeneous group of non-Hodgkin's lymphomas of skin-homing T cells. MF may vary from limited patchy skin disease to extensive cutaneous plaque and tumor involvement to extracutaneous compartments of blood, lymph nodes, and viscera. Advances in genomic technologies have enabled the increasing characterization of genetic alterations in this malignancy; using this technology, investigators hope to understand MF's variable behavior and pathogenesis. In this issue, Salgado et al. identify regions of genomic DNA alterations from 41 MF samples and report associations with prognosis.
Comment on
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Oligonucleotide array-CGH identifies genomic subgroups and prognostic markers for tumor stage mycosis fungoides.J Invest Dermatol. 2010 Apr;130(4):1126-35. doi: 10.1038/jid.2009.306. Epub 2009 Sep 17. J Invest Dermatol. 2010. PMID: 19759554
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