Mouse models to study the central regulation of puberty
- PMID: 20083157
- DOI: 10.1016/j.mce.2010.01.015
Mouse models to study the central regulation of puberty
Abstract
At puberty, the mammalian reproductive axis is activated by neuroendocrine events within the hypothalamus that initiate pulsatile secretion of gonadotropin releasing hormone (GnRH) to activate the pituitary/gonadal axis. Thus, puberty is critically dependent on the integrity of GnRH neuronal activity. Defects in the migration of GnRH neurons into the forebrain during development or in GnRH synthesis or release prevent pubertal maturation of the reproductive axis. Both naturally occurring and genetically modified mutant mice have provided valuable information about the cellular and molecular events required for normal pubertal development. This review focuses specifically on the molecules that have been identified from studies in mutant mice that act centrally to control entry into puberty.
Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved.
Similar articles
-
Neurobiological mechanisms underlying kisspeptin activation of gonadotropin-releasing hormone (GnRH) neurons at puberty.Mol Cell Endocrinol. 2010 Aug 5;324(1-2):45-50. doi: 10.1016/j.mce.2010.01.026. Epub 2010 Jan 28. Mol Cell Endocrinol. 2010. PMID: 20109523 Review.
-
Neuroendocrine mechanisms controlling female puberty: new approaches, new concepts.Int J Androl. 2006 Feb;29(1):256-63; discussion 286-90. doi: 10.1111/j.1365-2605.2005.00619.x. Int J Androl. 2006. PMID: 16466547 Review.
-
The neural basis of puberty and adolescence.Nat Neurosci. 2004 Oct;7(10):1040-7. doi: 10.1038/nn1326. Nat Neurosci. 2004. PMID: 15452575 Review.
-
Changes in the control of gonadotrophin secretion by neurotransmitters during sexual development in rats.Exp Clin Endocrinol Diabetes. 2001;109(4):188-95. doi: 10.1055/s-2001-15105. Exp Clin Endocrinol Diabetes. 2001. PMID: 11453030 Review.
-
Glia-to-neuron signaling and the neuroendocrine control of female puberty.Recent Prog Horm Res. 2000;55:197-223; discussion 223-4. Recent Prog Horm Res. 2000. PMID: 11036938 Review.
Cited by
-
The role of apelinergic system in metabolism and reproductive system in normal and pathological conditions: an overview.Front Endocrinol (Lausanne). 2023 Jun 22;14:1193150. doi: 10.3389/fendo.2023.1193150. eCollection 2023. Front Endocrinol (Lausanne). 2023. PMID: 37424869 Free PMC article. Review.
-
Whole exome sequencing identifies deleterious rare variants in CCDC141 in familial self-limited delayed puberty.NPJ Genom Med. 2021 Dec 20;6(1):107. doi: 10.1038/s41525-021-00274-w. NPJ Genom Med. 2021. PMID: 34930920 Free PMC article.
-
LGR4 deficiency results in delayed puberty through impaired Wnt/β-catenin signaling.JCI Insight. 2020 Jun 4;5(11):e133434. doi: 10.1172/jci.insight.133434. JCI Insight. 2020. PMID: 32493844 Free PMC article.
-
Delayed Puberty-Phenotypic Diversity, Molecular Genetic Mechanisms, and Recent Discoveries.Endocr Rev. 2019 Oct 1;40(5):1285-1317. doi: 10.1210/er.2018-00248. Endocr Rev. 2019. PMID: 31220230 Free PMC article. Review.
-
The Contribution of the Circadian Gene Bmal1 to Female Fertility and the Generation of the Preovulatory Luteinizing Hormone Surge.J Endocr Soc. 2019 Feb 13;3(4):716-733. doi: 10.1210/js.2018-00228. eCollection 2019 Apr 1. J Endocr Soc. 2019. PMID: 30906911 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Molecular Biology Databases
