Hippocampal volume in first episode and recurrent depression
- PMID: 19800203
- DOI: 10.1016/j.pscychresns.2008.08.001
Hippocampal volume in first episode and recurrent depression
Abstract
Abnormalities in limbic-thalamic-cortical networks are hypothesized to modulate human mood states. In the present study differences in hippocampal volumes of patients with a first episode of depression, recurrent major depression and healthy control subjects were examined with high-resolution magnetic resonance imaging (MRI). Male patients with a first episode of major depression had a significantly smaller left hippocampal volume than male control subjects. Also, these patients had a significant left-right asymmetry in hippocampal volume. Female patients showed no significant alterations in hippocampal volumes. The results support the hypothesis that the hippocampus plays an important role in the pathophysiology of the early phase of major depression, especially for male patients. Implications for the neurodevelopmental and the neurodegenerative model of hippocampal change are discussed.
Similar articles
-
Reduced hippocampal volume in unmedicated, remitted patients with major depression versus control subjects.Biol Psychiatry. 2005 Apr 15;57(8):935-7. doi: 10.1016/j.biopsych.2005.01.016. Biol Psychiatry. 2005. PMID: 15820716 Clinical Trial.
-
Life events and hippocampal volume in first-episode major depression.J Affect Disord. 2008 Oct;110(3):241-7. doi: 10.1016/j.jad.2008.01.022. Epub 2008 Mar 5. J Affect Disord. 2008. PMID: 18321593
-
Altered T2* relaxation time of the hippocampus in major depressive disorder: implications of ultra-high field magnetic resonance imaging.J Psychiatr Res. 2010 Oct;44(14):881-6. doi: 10.1016/j.jpsychires.2010.02.014. Epub 2010 Mar 24. J Psychiatr Res. 2010. PMID: 20338580
-
Volumetric MRI studies of the hippocampus in major depressive disorder: Meanings of inconsistency and directions for future research.World J Biol Psychiatry. 2010 Feb;11(1):19-35. doi: 10.1080/15622970902737998. World J Biol Psychiatry. 2010. PMID: 19347777 Review.
-
Hippocampal volume reduction in first-episode and chronic schizophrenia: a review and meta-analysis.Neuroscientist. 2012 Apr;18(2):180-200. doi: 10.1177/1073858410395147. Epub 2011 Apr 29. Neuroscientist. 2012. PMID: 21531988 Review.
Cited by
-
Depression in Women: Potential Biological and Sociocultural Factors Driving the Sex Effect.Neuropsychobiology. 2024;83(1):2-16. doi: 10.1159/000531588. Epub 2024 Jan 25. Neuropsychobiology. 2024. PMID: 38272005 Free PMC article. Review.
-
Volumes of hippocampal subfields suggest a continuum between schizophrenia, major depressive disorder and bipolar disorder.Front Psychiatry. 2023 Jul 20;14:1191170. doi: 10.3389/fpsyt.2023.1191170. eCollection 2023. Front Psychiatry. 2023. PMID: 37547217 Free PMC article.
-
Brain-based Sex Differences in Depression: A Systematic Review of Neuroimaging Studies.Brain Imaging Behav. 2023 Oct;17(5):541-569. doi: 10.1007/s11682-023-00772-8. Epub 2023 Apr 14. Brain Imaging Behav. 2023. PMID: 37058182 Free PMC article. Review.
-
Biomarkers in the Rat Hippocampus and Peripheral Blood for an Early Stage of Mental Disorders Induced by Water Immersion Stress.Int J Mol Sci. 2023 Feb 5;24(4):3153. doi: 10.3390/ijms24043153. Int J Mol Sci. 2023. PMID: 36834565 Free PMC article.
-
Brain Networks Involved in Depression in Patients with Frontotemporal Dementia and Parkinson's Disease: An Exploratory Resting-State Functional Connectivity MRI Study.Diagnostics (Basel). 2022 Apr 12;12(4):959. doi: 10.3390/diagnostics12040959. Diagnostics (Basel). 2022. PMID: 35454007 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical