Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2009 Oct;99 Suppl 2(Suppl 2):S389-97.
doi: 10.2105/AJPH.2008.151332.

Compliance with multiple-dose vaccine schedules among older children, adolescents, and adults: results from a vaccine safety datalink study

Jennifer C Nelson  1 , Rachel C L Bittner, Lora Bounds, Shanshan Zhao, James Baggs, James G Donahue, Simon J Hambidge, Steven J Jacobsen, Nicola P Klein, Allison L Naleway, Kenneth M Zangwill, Lisa A Jackson
Affiliations

Compliance with multiple-dose vaccine schedules among older children, adolescents, and adults: results from a vaccine safety datalink study

Jennifer C Nelson et al. Am J Public Health. 2009 Oct.

Abstract

Objectives: We studied compliance with multiple-dose vaccine schedules, assessed factors associated with noncompliance, and examined timeliness of series completion among older children, adolescents, and adults.

Methods: We conducted a large, multisite, retrospective cohort study of older children, adolescents, and adults in the Vaccine Safety Datalink population from 1996 through 2004. We quantified the rates of completion of all required doses for varicella, hepatitis A, and hepatitis B vaccines according to their recommended schedules.

Results: Among those who received a first dose of varicella (n = 16 075), hepatitis A (n = 594 917), and hepatitis B (n = 590 445) vaccine, relatively few completed the series (55%-65% for hepatitis B vaccine and 40%-50% for hepatitis A and varicella vaccines in most age groups). Compliance was lowest among adolescents (35.9%) and Medicaid recipients (29.7%) who received varicella vaccine and among younger adult age groups who received hepatitis A vaccine (25%-35% across those age groups). Even among series completers, there was a relatively long interval of undervaccination between the first and last doses.

Conclusions: Compliance with multiple-dose vaccine series among older children, adolescents, and adults is suboptimal. Further evaluations of strategies to improve compliance in these populations are needed.

PubMed Disclaimer

Figures

FIGURE 1
FIGURE 1
Cumulative proportion of individuals who completed the vaccine series, by time (in days) since first dose for (a) the varicella vaccine, (b) the hepatitis A vaccine, and (c) the hepatitis B vaccine vaccine: Vaccine Safety Datalink, 1996–2004.
FIGURE 1
FIGURE 1
Cumulative proportion of individuals who completed the vaccine series, by time (in days) since first dose for (a) the varicella vaccine, (b) the hepatitis A vaccine, and (c) the hepatitis B vaccine vaccine: Vaccine Safety Datalink, 1996–2004.
FIGURE 1
FIGURE 1
Cumulative proportion of individuals who completed the vaccine series, by time (in days) since first dose for (a) the varicella vaccine, (b) the hepatitis A vaccine, and (c) the hepatitis B vaccine vaccine: Vaccine Safety Datalink, 1996–2004.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Centers for Disease Control and Prevention. Prevention of varicella: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep. 1996;45(RR-11):1–36. - PubMed
    1. Centers for Disease Control and Prevention. Prevention of hepatitis A through active or passive immunization: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep. 1996;45(RR-15):1–30. - PubMed
    1. Centers for Disease Control and Prevention. Recommendation of the Immunization Practices Advisory Committee (ACIP). Inactivated hepatitis B virus vaccine. MMWR Morb Mortal Wkly Rep. 1982;31(24):317–322, 327–318. - PubMed
    1. Centers for Disease Control and Prevention. Hepatitis B virus: a comprehensive strategy for eliminating transmission in the United States through universal childhood vaccination. Recommendations of the Immunization Practices Advisory Committee (ACIP). MMWR Recomm Rep. 1991;40(RR-13):1–25. - PubMed
    1. Markowitz LE, Dunne EF, Saraiya M, Lawson HW, Chesson H, Unger ER. Quadrivalent human papillomavirus vaccine: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep. 2007;56(RR-2):1–24. - PubMed

Publication types

LinkOut - more resources