Autophagy-A double-edged sword in oncology
- PMID: 19452527
- DOI: 10.1002/ijc.24500
Autophagy-A double-edged sword in oncology
Abstract
Autophagy or "self-eating" digests proteins and functionless cell organelles to reuse. This cell-own recycling system attracts much attention in tumour biology. One of the major functions of autophagy is maintaining cellular homeostasis. Thus, it is constitutive active in all living cells. Damaged or dispensable proteins and organelles are removed to regulate composition and size of the cytoplasm. Many therapeutic treatments have been shown to modulate autophagy signalling although it is still unclear if autophagy represents a survival or a suicide mechanism for tumour cells. Tumour growth in response to blocked autophagy as well as tumour growth in response to induced autophagy has been described. Several recent review articles address the differential effect of autophagy manipulation to apoptosis signalling. However, less has been reported about interactions of autophagy manipulation to the outcome of cancer therapy and tumour growth. Therefore, this review tries to fill this gap. We discuss data demonstrating that cellular decisions to autophagy manipulation depend on tumour type, stage, microenvironment, autophagy initiator or inhibitor and combined tumour treatment. Finally, we come to the conclusion that further analyses are necessary before manipulation of autophagic mechanisms can find its way into tumour therapy for improved treatment of patients.
2009 UICC.
Similar articles
-
Therapeutic strategies of drug repositioning targeting autophagy to induce cancer cell death: from pathophysiology to treatment.J Hematol Oncol. 2017 Mar 9;10(1):67. doi: 10.1186/s13045-017-0436-9. J Hematol Oncol. 2017. PMID: 28279189 Free PMC article. Review.
-
Is targeting autophagy mechanism in cancer a good approach? The possible double-edge sword effect.Cell Biosci. 2021 Mar 20;11(1):56. doi: 10.1186/s13578-021-00570-z. Cell Biosci. 2021. PMID: 33743781 Free PMC article. Review.
-
Autophagy in tumour suppression and promotion.Mol Oncol. 2009 Aug;3(4):366-75. doi: 10.1016/j.molonc.2009.05.007. Epub 2009 Jun 6. Mol Oncol. 2009. PMID: 19559660 Free PMC article. Review.
-
Molecular regulation of autophagy in a pro-inflammatory tumour microenvironment: New insight into the role of serum amyloid A.Cytokine Growth Factor Rev. 2021 Jun;59:71-83. doi: 10.1016/j.cytogfr.2021.01.007. Epub 2021 Feb 6. Cytokine Growth Factor Rev. 2021. PMID: 33727011 Review.
-
The double-edged sword of autophagy modulation in cancer.Clin Cancer Res. 2009 Sep 1;15(17):5308-16. doi: 10.1158/1078-0432.CCR-07-5023. Epub 2009 Aug 25. Clin Cancer Res. 2009. PMID: 19706824 Free PMC article. Review.
Cited by
-
The Question of Survival or Death: What Is the Role of Autophagy in Acute Myeloid Leukemia (AML)?Int J Hematol Oncol Stem Cell Res. 2022 Oct 1;16(4):250-263. doi: 10.18502/ijhoscr.v16i4.10883. Int J Hematol Oncol Stem Cell Res. 2022. PMID: 36883106 Free PMC article. Review.
-
Glucocorticoid-induced microRNA-378 signaling mediates the progression of pancreatic cancer by enhancing autophagy.Cell Death Dis. 2022 Dec 19;13(12):1052. doi: 10.1038/s41419-022-05503-3. Cell Death Dis. 2022. PMID: 36535942 Free PMC article.
-
Enabling factor for cancer hallmark acquisition: Small nucleolar RNA host gene 17.Front Oncol. 2022 Sep 14;12:974939. doi: 10.3389/fonc.2022.974939. eCollection 2022. Front Oncol. 2022. PMID: 36185210 Free PMC article. Review.
-
Recombinant virus expressing hIFN-λ1 (rL-hIFN-λ1) has important effects on endoplasmic reticulum stress, autophagy and apoptosis in small cell lung cancer.Transl Cancer Res. 2020 Sep;9(9):5209-5217. doi: 10.21037/tcr-20-1205. Transl Cancer Res. 2020. PMID: 35117888 Free PMC article.
-
Establishment of Tumor Treating Fields Combined With Mild Hyperthermia as Novel Supporting Therapy for Pancreatic Cancer.Front Oncol. 2021 Nov 3;11:738801. doi: 10.3389/fonc.2021.738801. eCollection 2021. Front Oncol. 2021. PMID: 34804927 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Miscellaneous