Regimen complexity and medication nonadherence in elderly patients
- PMID: 19436625
- PMCID: PMC2697531
- DOI: 10.2147/tcrm.s4870
Regimen complexity and medication nonadherence in elderly patients
Abstract
Objective: To assess whether the number of daily administrations of individual drugs, as a measure of regimen complexity, contributes to the profile of an elderly patient who adheres poorly to the prescribed therapy.
Population: Six hundred ninety patients over 64 years who were consecutively admitted to 11 acute medical care and three long term/rehabilitation wards in Italy.
Main outcome measure: Self-reported adherence to drugs taken at home before admission was measured by a single question assessment for each listed drug supplemented with a latter question about the circumstances of the missed administration. For cognitively impaired patients the question was put to patients' relatives or caregivers.
Methods: A structured multidimensional assessment was performed to identify nonadherence and its potential correlates. Correlates of nonadherence were identified by multivariable logistic regression.
Results: We recorded 44 cases (6.4%) of nonadherence to at least one drug. Being assisted by foreign caregivers (OR 2.17; 95% CI 1.02-4.63) and the use of at least one multiple daily dosing drug (OR 2.99; 95% CI 1.24-7.17) were significant independent correlates of medication nonadherence, while age, selected indexes of frailty and the cumulative number of prescribed drugs were not.
Conclusion: Regimen complexity and type of assistance are independent correlates of medication nonadherence.
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References
-
- Dorz S, Lazzarini L, Cattelan A, et al. Evaluation of adherence to antiretroviral therapy in Italian HIV patients. AIDS Patient Care STDS. 2003;17:33–41. - PubMed
-
- Mallion J, Dutrey-Dupagne C, Vaur L, et al. Benefits of electronic pillboxes in evaluating treatment compliance of patients with mild to moderate hypertension. J Hypertens. 1996;14:137–144. - PubMed
-
- Benner J, Glynn R, Mogun H, et al. Long-term persistence in use of statin therapy in elderly patients. JAMA. 2002;288:455–461. - PubMed
-
- Bezie Y, Molina M, Hernandez N, et al. Therapeutic compliance: a prospective analysis of various factors involved in the adherence rate in type 2 diabetes. Diabetes Metab. 2006;32:611–616. - PubMed
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