Sex difference in pathology and memory decline in rTg4510 mouse model of tauopathy
- PMID: 19427061
- DOI: 10.1016/j.neurobiolaging.2009.04.006
Sex difference in pathology and memory decline in rTg4510 mouse model of tauopathy
Abstract
Abnormal phosphorylation of tau protein is a common event in many neurodegenerative disorders, including Alzheimer's disease and other tauopathies. We investigated the relationship between hyperphosphorylated tau in brain extracts and mnemonic functions in rTg4510 mouse model of tauopathy. We report that rTg4510 mice showed rapid deterioration in spatial learning and memory, which paralleled a significant increase of hyperphosphorylated tau in the brain between 3 and 5.5 months of age. At 5.5 months, rTg4510 females showed significantly higher levels of hyperphosphorylated tau than males, with no evidence of differential tau transgene expression between the sexes. The increased levels of hyperphosphorylated tau in females were associated with more severe impairment in spatial learning and memory as compared to transgenic males. We also showed that within studied age range, the decrease in memory performance was accompanied by other behavioral disturbances in the water maze related to search strategy, like thigmotaxic swim and cue response. These findings suggest that the onset of abnormal tau biochemistry and coincident cognitive deficits in the rTg4510 mouse model is sex-dependent with females being affected earlier and more aggressively than males.
Copyright © 2009 Elsevier Inc. All rights reserved.
Similar articles
-
A novel transgenic mouse expressing double mutant tau driven by its natural promoter exhibits tauopathy characteristics.Exp Neurol. 2008 Jul;212(1):71-84. doi: 10.1016/j.expneurol.2008.03.007. Epub 2008 Mar 21. Exp Neurol. 2008. PMID: 18490011
-
Hippocampal tauopathy in tau transgenic mice coincides with impaired hippocampus-dependent learning and memory, and attenuated late-phase long-term depression of synaptic transmission.Neurobiol Learn Mem. 2011 Mar;95(3):296-304. doi: 10.1016/j.nlm.2010.12.005. Epub 2010 Dec 16. Neurobiol Learn Mem. 2011. PMID: 21167950
-
3R tau expression modifies behavior in transgenic mice.J Neurosci Res. 2010 Sep;88(12):2727-35. doi: 10.1002/jnr.22431. J Neurosci Res. 2010. PMID: 20544828
-
Disruption of neuronal function by soluble hyperphosphorylated tau in a Drosophila model of tauopathy.Biochem Soc Trans. 2010 Apr;38(2):564-70. doi: 10.1042/BST0380564. Biochem Soc Trans. 2010. PMID: 20298222 Review.
-
Deletion of murine tau gene increases tau aggregation in a human mutant tau transgenic mouse model.Biochem Soc Trans. 2010 Aug;38(4):1001-5. doi: 10.1042/BST0381001. Biochem Soc Trans. 2010. PMID: 20658993 Review.
Cited by
-
Synaptic alterations associated with disrupted sensory encoding in a mouse model of tauopathy.Brain Commun. 2024 Apr 15;6(3):fcae134. doi: 10.1093/braincomms/fcae134. eCollection 2024. Brain Commun. 2024. PMID: 38712321 Free PMC article.
-
Insights on the Use of Transgenic Mice Models in Alzheimer's Disease Research.Int J Mol Sci. 2024 Feb 28;25(5):2805. doi: 10.3390/ijms25052805. Int J Mol Sci. 2024. PMID: 38474051 Free PMC article. Review.
-
Updates on mouse models of Alzheimer's disease.Mol Neurodegener. 2024 Mar 11;19(1):23. doi: 10.1186/s13024-024-00712-0. Mol Neurodegener. 2024. PMID: 38462606 Free PMC article. Review.
-
Sex-specific modulation of amyloid-β on tau phosphorylation underlies faster tangle accumulation in females.Brain. 2024 Apr 4;147(4):1497-1510. doi: 10.1093/brain/awad397. Brain. 2024. PMID: 37988283 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Molecular Biology Databases
