Increased ribosomal biogenesis induces pancreatic beta cell failure in mice model of type 2 diabetes
- PMID: 19309774
- DOI: 10.1016/j.bbrc.2009.02.047
Increased ribosomal biogenesis induces pancreatic beta cell failure in mice model of type 2 diabetes
Abstract
Aim: To study the changes in gene expression by pancreatic beta cells under insulin resistance conditions.
Method: An exhaustive gene expression analysis was performed, using isolated pancreatic islets of obese diabetic model Lepr(-/-) mice. Overexpression of cyclin D2 was induced in cells from the pancreatic beta cell line, namely, INS-1.
Results: Through a gene expression analysis using islets isolated from db/db mice, we found a significant increase in the expression of ribosome-related molecules. In addition, increased expression of cyclin D2 was found at certain protein levels. As INS-1 cells were induced to overexpress cyclin D2, we found an increase in the expression of ribosome-related molecules. Concurrently, an increase in the expression of endoplasmic reticulum stress (ER stress)-related molecules was also found.
Conclusion: In cases of pancreatic beta cell hyperplasia associated with insulin resistance, ribosomal biogenesis is increased, and ER stress is induced.
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