Association of common variants in NPPA and NPPB with circulating natriuretic peptides and blood pressure
- PMID: 19219041
- PMCID: PMC2664511
- DOI: 10.1038/ng.328
Association of common variants in NPPA and NPPB with circulating natriuretic peptides and blood pressure
Abstract
We examined the association of common variants at the NPPA-NPPB locus with circulating concentrations of the natriuretic peptides, which have blood pressure-lowering properties. We genotyped SNPs at the NPPA-NPPB locus in 14,743 individuals of European ancestry, and identified associations of plasma atrial natriuretic peptide with rs5068 (P = 8 x 10(-70)), rs198358 (P = 8 x 10(-30)) and rs632793 (P = 2 x 10(-10)), and of plasma B-type natriuretic peptide with rs5068 (P = 3 x 10(-12)), rs198358 (P = 1 x 10(-25)) and rs632793 (P = 2 x 10(-68)). In 29,717 individuals, the alleles of rs5068 and rs198358 that showed association with increased circulating natriuretic peptide concentrations were also found to be associated with lower systolic (P = 2 x 10(-6) and 6 x 10(-5), respectively) and diastolic blood pressure (P = 1 x 10(-6) and 5 x 10(-5)), as well as reduced odds of hypertension (OR = 0.85, 95% CI = 0.79-0.92, P = 4 x 10(-5); OR = 0.90, 95% CI = 0.85-0.95, P = 2 x 10(-4), respectively). Common genetic variants at the NPPA-NPPB locus found to be associated with circulating natriuretic peptide concentrations contribute to interindividual variation in blood pressure and hypertension.
Conflict of interest statement
Dr. Bloch has sponsored research agreements with and serves on the scientific advisory board of IKARIA/INOTherapeutics. Dr. Bloch reports no conflicts of interest related to this manuscript. Drs. Struck, Morgenthaler and Bergmann are employees of and Dr. Bergmann holds stock in BRAHMS, AG. BRAHMS, AG holds patent rights on the midregional pro-ANP assay. Dr. Hirschhorn has an equity interest in and receives consulting fees from Correlagen Diagnostics. No other potential conflict of interest relevant to this article was reported.
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