Small cell neuroendocrine carcinoma of the cervix: Analysis of outcome, recurrence pattern and the impact of platinum-based combination chemotherapy
- PMID: 19110302
- DOI: 10.1016/j.ygyno.2008.11.010
Small cell neuroendocrine carcinoma of the cervix: Analysis of outcome, recurrence pattern and the impact of platinum-based combination chemotherapy
Abstract
Objectives: To analyze progression-free (PFS) and overall survival (OS) in patients with small cell neuroendocrine carcinoma of the cervix (SCNEC), and to determine whether platinum-based combination chemotherapy is beneficial for this population.
Methods: We performed a retrospective analysis of all patients with SCNEC who were treated at our institution between 1/1990 and 2/2007. Patients were excluded if pathologic diagnosis was not confirmed at our institution. Standard statistical methods were utilized.
Results: Seventeen patients met inclusion criteria. The estimated 3-year PFS and OS rates for the entire group were 22% and 30%, respectively. Median time to progression was 9.1 months. Extent of disease was the only significant prognostic factor. Median OS for patients with early stage disease (IA1-IB2) was 31.2 months and 6.4 months for patients with advanced stage disease (IIB-IV, P=0.034). In the early-stage disease group, the 3-year distant recurrence-free survival rate was 83% for patients who received chemotherapy and 0% for patients who did not receive chemotherapy as part of their initial treatment (P=0.025). The estimated 3-year OS rate was 83% for patients who received and 20% for patients who did not receive chemotherapy as part of their initial treatment (P=0.36).
Conclusion: Given the rarity of SCNEC this retrospective analysis is limited by a small number of patients. However, the natural history of this rare disease is akin to small cell lung cancer and the prognosis is poor due to the tumor's propensity for distant spread. The treatment should conform to the treatment of small cell lung cancer.
Similar articles
-
Chemotherapy for small cell lung carcinoma: the Greenlane Hospital experience 1993-1995.N Z Med J. 1998 Nov 27;111(1078):451-2, 453-4. N Z Med J. 1998. PMID: 9891564
-
Multimodality therapy in early-stage neuroendocrine carcinoma of the uterine cervix.Gynecol Oncol. 2001 Apr;81(1):82-7. doi: 10.1006/gyno.2000.6118. Gynecol Oncol. 2001. PMID: 11277655
-
Small cell neuroendocrine carcinoma of the cervix: outcome and patterns of recurrence.Gynecol Oncol. 2004 Apr;93(1):27-33. doi: 10.1016/j.ygyno.2003.12.027. Gynecol Oncol. 2004. PMID: 15047210
-
Small cell carcinoma of the esophagus: the University of Texas M. D. Anderson Cancer Center experience and literature review.Cancer. 2000 Jan 15;88(2):262-7. Cancer. 2000. PMID: 10640955 Review.
-
Neuroendocrine small cell carcinoma of the uterine cervix showing polypoid growth and complicated by pregnancy.Gynecol Oncol. 2001 Apr;81(1):117-9. doi: 10.1006/gyno.2000.6117. Gynecol Oncol. 2001. PMID: 11277662 Review.
Cited by
-
Advancements in the Understanding of Small-Cell Neuroendocrine Cervical Cancer: Where We Stand and What Lies Ahead.J Pers Med. 2024 Apr 27;14(5):462. doi: 10.3390/jpm14050462. J Pers Med. 2024. PMID: 38793044 Free PMC article. Review.
-
Pan-Canadian Analysis of Practice Patterns in Small Cell Carcinoma of the Cervix: Insights from a Multidisciplinary Survey.Curr Oncol. 2024 May 3;31(5):2610-2619. doi: 10.3390/curroncol31050196. Curr Oncol. 2024. PMID: 38785477 Free PMC article.
-
Nodal infiltration in endometrial cancer: a prediction model using best subset regression.Eur Radiol. 2024 May;34(5):3375-3384. doi: 10.1007/s00330-023-10310-1. Epub 2023 Oct 26. Eur Radiol. 2024. PMID: 37882835
-
Incorporation of immunotherapy into the treatment of metastatic neuroendocrine carcinoma of the cervix: A case report.Gynecol Oncol Rep. 2023 Aug 22;49:101263. doi: 10.1016/j.gore.2023.101263. eCollection 2023 Oct. Gynecol Oncol Rep. 2023. PMID: 37663173 Free PMC article.
-
PD-L1 expression and prognosis in definitive radiotherapy patients with neuroendocrine cervical carcinoma.J Clin Transl Res. 2023 Jul 28;9(4):272-281. eCollection 2023 Aug 31. J Clin Transl Res. 2023. PMID: 37593242 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Miscellaneous