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Review
. 2008 Oct 12;363(1507):3137-46.
doi: 10.1098/rstb.2008.0093.

Review. The incentive sensitization theory of addiction: some current issues

Terry E Robinson  1 , Kent C Berridge
Affiliations
Review

Review. The incentive sensitization theory of addiction: some current issues

Terry E Robinson et al. Philos Trans R Soc Lond B Biol Sci. .

Abstract

We present a brief overview of the incentive sensitization theory of addiction. This posits that addiction is caused primarily by drug-induced sensitization in the brain mesocorticolimbic systems that attribute incentive salience to reward-associated stimuli. If rendered hypersensitive, these systems cause pathological incentive motivation ('wanting') for drugs. We address some current questions including: what is the role of learning in incentive sensitization and addiction? Does incentive sensitization occur in human addicts? Is the development of addiction-like behaviour in animals associated with sensitization? What is the best way to model addiction symptoms using animal models? And, finally, what are the roles of affective pleasure or withdrawal in addiction?

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References

    1. Ahmed S.H, Cador M. Dissociation of psychomotor sensitization from compulsive cocaine consumption. Neuropschopharmacology. 2006;31:563–571. doi:10.1038/sj.npp.1300834 - DOI - PubMed
    1. Ahmed S.H, Koob G.F. Transition from moderate to excessive drug intake: change in hedonic set point. Science. 1998;282:298–300. doi:10.1126/science.282.5387.298 - DOI - PubMed
    1. Ahmed S.H, Walker J.R, Koob G.F. Persistent increase in the motivation to take heroin in rats with a history of drug escalation. Neuropschopharmacology. 2000;22:413–421. doi:10.1016/S0893-133X(99)00133-5 - DOI - PubMed
    1. Ahmed S.H, Lutjens R, van der Stap L.D, Lekic D, Romano-Spica V, Morales M, Koob G.F, Repunte-Canonigo V, Sanna P.P. Gene expression evidence for remodeling of lateral hypothalamic circuitry in cocaine addiction. Proc. Natl Acad. Sci. USA. 2005;102:11 533–11 538. doi:10.1073/pnas.0504438102 - DOI - PMC - PubMed
    1. Anagnostaras S.G, Robinson T.E. Sensitization to the psychomotor stimulant effects of amphetamine: modulation by associative learning. Behav. Neurosci. 1996;110:1397–1414. doi:10.1037/0735-7044.110.6.1397 - DOI - PubMed

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