Evaluation of blood oxidative stress-related parameters in alcoholic liver disease and non-alcoholic fatty liver disease
- PMID: 18609067
- DOI: 10.1080/00365510701673383
Evaluation of blood oxidative stress-related parameters in alcoholic liver disease and non-alcoholic fatty liver disease
Abstract
Oxidative stress is implicated in the pathogenesis of liver disease. We investigated oxidative stress-related parameters and correlated with clinical findings in 35 non-alcoholic fatty liver disease (NAFLD) patients, 38 alcoholic liver disease (ALD) patients and 38 normal subjects. NAFLD patients showed significantly higher body mass index, cholesterol, LDL-cholesterol, VLDL-cholesterol levels and transaminase activities compared to the other two groups. Haematological parameters were significantly altered in ALD patients and were reported only in male subjects. Glutathione content, catalase activity, glutathione reductase activity and glutathione peroxidase activity in NAFLD patients were reduced by 10.7 %, 18.5 %, 8.1 % and 16.8 %, respectively, and in ALD patients by 21.8 %, 29.6 %, 24.3 % and 45.3 %, respectively, compared to the normal group. However, thiobarbituric acid reactive substance content, superoxide dismutase activity and glutathione s-transferase activity were increased by 35.2 %, 31.6 % and 5.4 %, respectively, in NAFLD patients, and in ALD patients by 75.2 %, 72.7 % and 32.4 %, respectively, compared to the normal group. Oxidative stress is associated with collagen production and leads to fibrosis. Type IV collagen level in NAFLD patients (190.6 +/- 83 ng/mL) was significantly higher than in the normal group (124.5 +/- 14.5 ng/mL) and lower than in ALD patients (373.4 +/- 170 ng/mL). While type IV collagen level of >124 ng/mL was a predictor of NAFLD patients from normal subjects, elevated ALT (>40 IU/L) activity could discriminate either of the liver disease patients from normal subjects.
Similar articles
-
Review article: current management of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis.Aliment Pharmacol Ther. 2008 Jul;28(1):2-12. doi: 10.1111/j.1365-2036.2008.03710.x. Epub 2008 Apr 11. Aliment Pharmacol Ther. 2008. PMID: 18410557 Review.
-
Genetics of alcoholic liver disease and nonalcoholic fatty liver disease.Semin Liver Dis. 2007 Feb;27(1):44-54. doi: 10.1055/s-2006-960170. Semin Liver Dis. 2007. PMID: 17295176 Review.
-
Oxidant stress and antioxidant status among patients with nonalcoholic fatty liver disease (NAFLD).J Clin Gastroenterol. 2006 Nov-Dec;40(10):930-5. doi: 10.1097/01.mcg.0000212608.59090.08. J Clin Gastroenterol. 2006. PMID: 17063114
-
Increase in liver antioxidant enzyme activities in non-alcoholic fatty liver disease.Liver Int. 2005 Oct;25(5):946-53. doi: 10.1111/j.1478-3231.2005.01126.x. Liver Int. 2005. PMID: 16162151
-
Oxidative stress-related parameters in the liver of non-alcoholic fatty liver disease patients.Clin Sci (Lond). 2004 Mar;106(3):261-8. doi: 10.1042/CS20030285. Clin Sci (Lond). 2004. PMID: 14556645
Cited by
-
Non-Alcoholic Fatty Liver Disease Is Associated with a Decreased Catalase (CAT) Level, CT Genotypes and the T Allele of the -262 C/T CAT Polymorphism.Cells. 2023 Sep 7;12(18):2228. doi: 10.3390/cells12182228. Cells. 2023. PMID: 37759451 Free PMC article.
-
Evaluation of Atherosclerotic Risk by Oxidative Contributors in Alcohol Use Disorder.Clin Psychopharmacol Neurosci. 2023 Aug 31;21(3):526-533. doi: 10.9758/cpn.22.1010. Clin Psychopharmacol Neurosci. 2023. PMID: 37424420 Free PMC article.
-
Functional metabolomics using UPLC-Q/TOF-MS combined with ingenuity pathway analysis as a promising strategy for evaluating the efficacy and discovering amino acid metabolism as a potential therapeutic mechanism-related target for geniposide against alcoholic liver disease.RSC Adv. 2020 Jan 15;10(5):2677-2690. doi: 10.1039/c9ra09305b. eCollection 2020 Jan 14. RSC Adv. 2020. PMID: 35496090 Free PMC article.
-
Catalase and nonalcoholic fatty liver disease.Pflugers Arch. 2018 Dec;470(12):1721-1737. doi: 10.1007/s00424-018-2195-z. Epub 2018 Aug 17. Pflugers Arch. 2018. PMID: 30120555 Review.
-
Effects of Karela (Bitter Melon; Momordica charantia) on genes of lipids and carbohydrates metabolism in experimental hypercholesterolemia: biochemical, molecular and histopathological study.BMC Complement Altern Med. 2017 Jun 17;17(1):319. doi: 10.1186/s12906-017-1833-x. BMC Complement Altern Med. 2017. PMID: 28623919 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical