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. 2008 Apr 26;336(7650):924-6.
doi: 10.1136/bmj.39489.470347.AD.

GRADE: an emerging consensus on rating quality of evidence and strength of recommendations

Gordon H Guyatt  1 , Andrew D Oxman, Gunn E Vist, Regina Kunz, Yngve Falck-Ytter, Pablo Alonso-Coello, Holger J Schünemann; GRADE Working Group
Collaborators, Affiliations

GRADE: an emerging consensus on rating quality of evidence and strength of recommendations

Gordon H Guyatt et al. BMJ. .

Abstract

Guidelines are inconsistent in how they rate the quality of evidence and the strength of recommendations. This article explores the advantages of the GRADE system, which is increasingly being adopted by organisations worldwide

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Conflict of interest statement

Competing interests: All authors are involved in the dissemination of GRADE, and GRADE’s success has a positive influence on their academic career. Authors listed in the byline have received travel reimbursement and honorariums for presentations that included a review of GRADE’s approach to rating quality of evidence and grading recommendations. GHG acts as a consultant to UpToDate; his work includes helping UpToDate in their use of GRADE. HJS is documents editor and methodologist for the American Thoracic Society; one of his roles in these positions is helping implement the use of GRADE. He is supported by “The human factor, mobility and Marie Curie actions scientist reintegration European Commission grant: IGR 42192—GRADE.”

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References

    1. Atkins D, Eccles M, Flottorp S, Guyatt GH, Henry D, Hill S, et al. Systems for grading the quality of evidence and the strength of recommendations I: critical appraisal of existing approaches. The GRADE Working Group. BMC Health Serv Res 2004;4(1):38. - PMC - PubMed
    1. Lacchetti C, Guyatt G. Surprising results of randomized trials. In: Guyatt G, Drummond R, eds. Users’ guides to the medical literature: a manual of evidence-based clinical practice Chicago, IL: AMA Press, 2002
    1. American College of Physicians. Guidelines for counseling postmenopausal women about preventive hormone therapy. Ann Intern Med 1992;117:1038-41. - PubMed
    1. Humphrey LL, Chan BK, Sox HC. Postmenopausal hormone replacement therapy and the primary prevention of cardiovascular disease. Ann Intern Med 2002;137:273-84. - PubMed
    1. Hulley S, Grady D, Bush T, Furberg C, Herrington D, Riggs B, et al. Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. Heart and Estrogen/progestin Replacement Study (HERS) Research Group. JAMA 1998;280:605-13. - PubMed

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