Evidence for editing of human papillomavirus DNA by APOBEC3 in benign and precancerous lesions
- PMID: 18403710
- DOI: 10.1126/science.1153201
Evidence for editing of human papillomavirus DNA by APOBEC3 in benign and precancerous lesions
Abstract
Cytidine deaminases of the APOBEC3 family all have specificity for single-stranded DNA, which may become exposed during replication or transcription of double-stranded DNA. Three human APOBEC3A (hA3A), hA3B, and hA3H genes are expressed in keratinocytes and skin, leading us to determine whether genetic editing of human papillomavirus (HPV) DNA occurred. In a study of HPV1a plantar warts and HPV16 precancerous cervical biopsies, hyperedited HPV1a and HPV16 genomes were found. Strictly analogous results were obtained from transfection experiments with HPV plasmid DNA and the three nuclear localized enzymes: hA3A, hA3C, and hA3H. Thus, stochastic or transient overexpression of APOBEC3 genes may expose the genome to a broad spectrum of mutations that could influence the development of tumors.
Similar articles
-
APOBEC3A functions as a restriction factor of human papillomavirus.J Virol. 2015 Jan;89(1):688-702. doi: 10.1128/JVI.02383-14. Epub 2014 Oct 29. J Virol. 2015. PMID: 25355878 Free PMC article.
-
APOBEC3 deaminases induce hypermutation in human papillomavirus 16 DNA upon beta interferon stimulation.J Virol. 2014 Jan;88(2):1308-17. doi: 10.1128/JVI.03091-13. Epub 2013 Nov 13. J Virol. 2014. PMID: 24227842 Free PMC article.
-
Mutations in the HPV16 genome induced by APOBEC3 are associated with viral clearance.Nat Commun. 2020 Feb 14;11(1):886. doi: 10.1038/s41467-020-14730-1. Nat Commun. 2020. PMID: 32060290 Free PMC article.
-
High-risk HPV DNA testing and HPV-16/18 genotyping: what is the clinical application?J Low Genit Tract Dis. 2011 Jul;15(3):224-30. doi: 10.1097/LGT.0b013e3181fb46d8. J Low Genit Tract Dis. 2011. PMID: 21716051 Review.
-
Roles of APOBEC3A and APOBEC3B in Human Papillomavirus Infection and Disease Progression.Viruses. 2017 Aug 21;9(8):233. doi: 10.3390/v9080233. Viruses. 2017. PMID: 28825669 Free PMC article. Review.
Cited by
-
Prevalence of cervical intraepithelial lesions and associated factors among women attending a cervical cancer clinic in Western Uganda; results based on Pap smear cytology.SAGE Open Med. 2024 May 16;12:20503121241252265. doi: 10.1177/20503121241252265. eCollection 2024. SAGE Open Med. 2024. PMID: 38764539 Free PMC article.
-
Understanding the biology of monkeypox virus to prevent future outbreaks.Nat Microbiol. 2024 Jun;9(6):1408-1416. doi: 10.1038/s41564-024-01690-1. Epub 2024 May 9. Nat Microbiol. 2024. PMID: 38724757 Review.
-
The Intricate Interplay between APOBEC3 Proteins and DNA Tumour Viruses.Pathogens. 2024 Feb 20;13(3):187. doi: 10.3390/pathogens13030187. Pathogens. 2024. PMID: 38535531 Free PMC article. Review.
-
Anelloviruses versus human immunity: how do we control these viruses?FEMS Microbiol Rev. 2024 Jan 12;48(1):fuae005. doi: 10.1093/femsre/fuae005. FEMS Microbiol Rev. 2024. PMID: 38337179 Free PMC article. Review.
-
The Impact of First-Time SARS-CoV-2 Infection on Human Anelloviruses.Viruses. 2024 Jan 9;16(1):99. doi: 10.3390/v16010099. Viruses. 2024. PMID: 38257799 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Molecular Biology Databases