Review
doi: 10.1016/j.cmet.2008.03.008.
Iron homeostasis: fitting the puzzle pieces together
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- PMID: 18396134
- DOI: 10.1016/j.cmet.2008.03.008
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Review
Iron homeostasis: fitting the puzzle pieces together
Cell Metab.
2008 Apr.
Free article
Abstract
Here, recent insights into iron homeostasis are highlighted. Three studies demonstrate the importance of the IRE-IRP system for enterocytes in balancing extracellular iron demand against cellular iron requirements, show that the hemochromatosis protein HFE exerts its iron-regulatory activity principally in hepatocytes by modulating the production of hepcidin, and provide strong support for a proposed mechanism of transcriptional regulation of hepcidin through a signaling cascade initiated by holotransferrin displacing HFE from transferrin receptor 1.
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