Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2008 Jul;61(7):818-24.
doi: 10.1136/jcp.2007.054866. Epub 2008 Apr 1.

HER2 testing in the UK: further update to recommendations

R A Walker  1 , J M S Bartlett, M Dowsett, I O Ellis, A M Hanby, B Jasani, K Miller, S E Pinder
Affiliations
Review

HER2 testing in the UK: further update to recommendations

R A Walker et al. J Clin Pathol. 2008 Jul.

Abstract

These guidelines update the previous UK HER2 testing guidelines and have been formulated to give advice on methodology, interpretation and quality assurance to ensure that HER2 testing results are accurate, reliable and timely with the expansion of testing to all patients with breast cancer at the time of primary diagnosis. The recommendations for testing are the use of immunohistochemistry but with analysis of equivocal cases by in situ hybridisation to clarify their HER2 status or the use of frontline fluorescence in situ hybridisation (FISH) testing for those laboratories wishing to do so; the inclusion of a chromosome 17 probe is strongly recommended. Laboratories using chromogenic or silver in situ hybridisation should perform an initial validation against FISH. For immunohistochemistry and in situ hybridisation there must be participation in the appropriate National External Quality Assurance scheme.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles