Myocarditis, pericarditis, and dilated cardiomyopathy after smallpox vaccination among civilians in the United States, January-October 2003
- PMID: 18284365
- DOI: 10.1086/524747
Myocarditis, pericarditis, and dilated cardiomyopathy after smallpox vaccination among civilians in the United States, January-October 2003
Abstract
Myocarditis was reported after smallpox vaccination in Europe and Australia, but no association had been reported with the US vaccine. We conducted surveillance to describe and determine the frequency of myocarditis and/or pericarditis (myo/pericarditis) among civilians vaccinated during the US smallpox vaccination program between January and October 2003. We developed surveillance case definitions for myocarditis, pericarditis, and dilated cardiomyopathy after smallpox vaccination. We identified 21 myo/pericarditis cases among 37,901 vaccinees (5.5 per 10,000); 18 (86%) were revacinees, 14 (67%) were women, and the median age was 48 years (range, 25-70 years). The median time from vaccination to onset of symptoms was 11 days (range, 2-42 days). Myo/pericarditis severity was mild, with no fatalities, although 9 patients (43%) were hospitalized. Three additional vaccinees were found to have dilated cardiomyopathy, recognized within 3 months after vaccination. We describe an association between smallpox vaccination, using the US vaccinia strain, and myo/pericarditis among civilians.
Similar articles
-
Monitoring the safety of a smallpox vaccination program in the United States: report of the joint Smallpox Vaccine Safety Working Group of the advisory committee on immunization practices and the Armed Forces Epidemiological Board.Clin Infect Dis. 2008 Mar 15;46 Suppl 3:S258-70. doi: 10.1086/524749. Clin Infect Dis. 2008. PMID: 18284367
-
Economics of cardiac adverse events after smallpox vaccination: lessons from the 2003 US Vaccination Program.Clin Infect Dis. 2008 Mar 15;46 Suppl 3:S168-78. doi: 10.1086/524380. Clin Infect Dis. 2008. PMID: 18284356
-
The US smallpox vaccination program: a review of a large modern era smallpox vaccination implementation program.Vaccine. 2005 Mar 18;23(17-18):2078-81. doi: 10.1016/j.vaccine.2005.01.012. Vaccine. 2005. PMID: 15755574 Review.
-
Incidence and follow-up of inflammatory cardiac complications after smallpox vaccination.J Am Coll Cardiol. 2004 Jul 7;44(1):201-5. doi: 10.1016/j.jacc.2004.05.004. J Am Coll Cardiol. 2004. PMID: 15234435 Review.
-
Update: cardiac and other adverse events following civilian smallpox vaccination--United States, 2003.MMWR Morb Mortal Wkly Rep. 2003 Jul 11;52(27):639-42. MMWR Morb Mortal Wkly Rep. 2003. PMID: 12855946
Cited by
-
Monkeypox virus infection and myocarditis: A review of current evidence and possible pathogenesis.Narra J. 2023 Apr;3(1):e104. doi: 10.52225/narra.v3i1.104. Epub 2023 Apr 20. Narra J. 2023. PMID: 38450040 Free PMC article. Review.
-
Vaccination-Associated Myocarditis and Myocardial Injury.Circ Res. 2023 May 12;132(10):1338-1357. doi: 10.1161/CIRCRESAHA.122.321881. Epub 2023 May 11. Circ Res. 2023. PMID: 37167355 Free PMC article. Review.
-
Single Dose of Recombinant Chimeric Horsepox Virus (TNX-801) Vaccination Protects Macaques from Lethal Monkeypox Challenge.Viruses. 2023 Jan 26;15(2):356. doi: 10.3390/v15020356. Viruses. 2023. PMID: 36851570 Free PMC article.
-
Monkeypox induced acute myocarditis in a young healthy adult.JAAD Case Rep. 2023 Apr;34:5-6. doi: 10.1016/j.jdcr.2023.01.018. Epub 2023 Feb 3. JAAD Case Rep. 2023. PMID: 36776939 Free PMC article. No abstract available.
-
Case Report: Mpox - Not Just a Rash.Am J Trop Med Hyg. 2023 Jan 30;108(3):592-594. doi: 10.4269/ajtmh.22-0626. Print 2023 Mar 1. Am J Trop Med Hyg. 2023. PMID: 36716741 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical