Inactivated influenza vaccine (IIV) in children <2 years of age: examination of selected adverse events reported to the Vaccine Adverse Event Reporting System (VAERS) after thimerosal-free or thimerosal-containing vaccine
- PMID: 18093701
- DOI: 10.1016/j.vaccine.2007.10.071
Inactivated influenza vaccine (IIV) in children <2 years of age: examination of selected adverse events reported to the Vaccine Adverse Event Reporting System (VAERS) after thimerosal-free or thimerosal-containing vaccine
Abstract
Thimerosal as a preservative (in all but trace amounts) was removed from vaccines used in infants starting in the late 1990s, though the preservative-including inactivated influenza vaccine is still available for use in individuals >or=6 months of age. We compared the proportion of injection site reactions, rash, and infections reported to the Vaccine Adverse Event Reporting System (VAERS) after preservative-free (PFV), preservative-including (PIV), and preservative unknown (PUV) vaccines in reports from 7/1/2004 to 1/4/2006. There were 145, 175, and 216 reports after vaccination with PFV, PIV, and PUV, respectively. The most frequently reported coding terms (fever, rash, and urticaria) were seen in similar proportions in the PFV, PIV, and PUV groups. No difference was detected in the proportion of injection site reactions (ISR), rash, or infections in the PIV, PFV, and PUV reports. Keeping in mind the inherent limitations of VAERS, including underreporting and potential reporting biases, we conclude that there were no substantial differences in the proportion of rash, ISR, and infection reports in the PIV, PFV and PUV reports in infants.
Similar articles
-
Elective termination of pregnancy after vaccination reported to the Vaccine Adverse Event Reporting System (VAERS): 1990-2006.Vaccine. 2008 May 2;26(19):2428-32. doi: 10.1016/j.vaccine.2008.02.052. Epub 2008 Mar 17. Vaccine. 2008. PMID: 18406499 Review.
-
Live attenuated measles and mumps viral strain-containing vaccines and hearing loss: Vaccine Adverse Event Reporting System (VAERS), United States, 1990--2003.Vaccine. 2008 Feb 26;26(9):1166-72. doi: 10.1016/j.vaccine.2007.12.049. Epub 2008 Jan 22. Vaccine. 2008. PMID: 18255204 Review.
-
Neurodevelopmental disorders following thimerosal-containing childhood immunizations: a follow-up analysis.Int J Toxicol. 2004 Nov-Dec;23(6):369-76. doi: 10.1080/10915810490902038. Int J Toxicol. 2004. PMID: 15764492
-
Adverse events after inactivated influenza vaccination among children less than 2 years of age: analysis of reports from the vaccine adverse event reporting system, 1990-2003.Pediatrics. 2005 Feb;115(2):453-60. doi: 10.1542/peds.2004-1519. Pediatrics. 2005. PMID: 15687455
-
Surveillance for safety after immunization: Vaccine Adverse Event Reporting System (VAERS)--United States, 1991-2001.MMWR Surveill Summ. 2003 Jan 24;52(1):1-24. MMWR Surveill Summ. 2003. PMID: 12825543
Cited by
-
Allergic Reactions to Vaccines in Children: From Constituents to Specific Vaccines.Biomedicines. 2023 Feb 18;11(2):620. doi: 10.3390/biomedicines11020620. Biomedicines. 2023. PMID: 36831156 Free PMC article. Review.
-
Trends in Web Searches About the Causes and Treatments of Autism Over the Past 15 Years: Exploratory Infodemiology Study.JMIR Pediatr Parent. 2020 Dec 7;3(2):e20913. doi: 10.2196/20913. JMIR Pediatr Parent. 2020. PMID: 33284128 Free PMC article.
-
Risk Of Urticaria In Geriatric Stroke Patients Who Received Influenza Vaccination: A Retrospective Cohort Study.Clin Interv Aging. 2019 Nov 26;14:2085-2093. doi: 10.2147/CIA.S228324. eCollection 2019. Clin Interv Aging. 2019. PMID: 32063700 Free PMC article.
-
Vaccines for preventing influenza in healthy children.Cochrane Database Syst Rev. 2018 Feb 1;2(2):CD004879. doi: 10.1002/14651858.CD004879.pub5. Cochrane Database Syst Rev. 2018. PMID: 29388195 Free PMC article. Review.
-
A case of myositis of the deltoid muscle of the upper arm developing 1 week after influenza vaccination: case report.Clin Case Rep. 2015 Mar;3(3):135-8. doi: 10.1002/ccr3.177. Epub 2014 Nov 27. Clin Case Rep. 2015. PMID: 25838900 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical