Review
doi: 10.1101/gad.1599207.
Autophagy: process and function
Affiliations
- PMID: 18006683
- DOI: 10.1101/gad.1599207
Item in Clipboard
Review
Autophagy: process and function
Genes Dev.
.
Free article
Abstract
Autophagy is an intracellular degradation system that delivers cytoplasmic constituents to the lysosome. Despite its simplicity, recent progress has demonstrated that autophagy plays a wide variety of physiological and pathophysiological roles, which are sometimes complex. Autophagy consists of several sequential steps--sequestration, transport to lysosomes, degradation, and utilization of degradation products--and each step may exert different function. In this review, the process of autophagy is summarized, and the role of autophagy is discussed in a process-based manner.
Similar articles
-
Autophagy: cells SNARE selves.Curr Biol. 2011 Sep 27;21(18):R697-9. doi: 10.1016/j.cub.2011.08.017. Curr Biol. 2011. PMID: 21959158
-
PLEKHM1 regulates autophagosome-lysosome fusion through HOPS complex and LC3/GABARAP proteins.Mol Cell. 2015 Jan 8;57(1):39-54. doi: 10.1016/j.molcel.2014.11.006. Epub 2014 Dec 11. Mol Cell. 2015. PMID: 25498145
-
Assortment of phosphatidylinositol 3-kinase complexes--Atg14p directs association of complex I to the pre-autophagosomal structure in Saccharomyces cerevisiae.Mol Biol Cell. 2006 Apr;17(4):1527-39. doi: 10.1091/mbc.e05-09-0841. Epub 2006 Jan 18. Mol Biol Cell. 2006. PMID: 16421251 Free PMC article.
-
Approaching the molecular mechanism of autophagy.Traffic. 2001 Aug;2(8):524-31. doi: 10.1034/j.1600-0854.2001.20802.x. Traffic. 2001. PMID: 11489210 Review.
-
Autophagosome maturation and lysosomal fusion.Essays Biochem. 2013;55:65-78. doi: 10.1042/bse0550065. Essays Biochem. 2013. PMID: 24070472 Review.
Cited by
-
p20BAP31 Induces Autophagy in Colorectal Cancer Cells by Promoting PERK-Mediated ER Stress.Int J Mol Sci. 2024 May 7;25(10):5101. doi: 10.3390/ijms25105101. Int J Mol Sci. 2024. PMID: 38791141 Free PMC article.
-
Traumatic brain injury heterogeneity affects cell death and autophagy.Exp Brain Res. 2024 Jul;242(7):1645-1658. doi: 10.1007/s00221-024-06856-1. Epub 2024 May 24. Exp Brain Res. 2024. PMID: 38789796
-
AGC1-mediated Metabolic Reprogramming and Autophagy Sustain Survival of Hepatocellular Carcinoma Cells under Glutamine Deprivation.Cell Biochem Biophys. 2024 May 24. doi: 10.1007/s12013-024-01311-y. Online ahead of print. Cell Biochem Biophys. 2024. PMID: 38789662
-
Tumor biomarkers for diagnosis, prognosis and targeted therapy.Signal Transduct Target Ther. 2024 May 20;9(1):132. doi: 10.1038/s41392-024-01823-2. Signal Transduct Target Ther. 2024. PMID: 38763973 Free PMC article. Review.
-
Autophagy favors survival of corpora lutea during the long-lasting pregnancy of the South American plains vizcacha, Lagostomus maximus (Rodentia, Caviomorpha).Sci Rep. 2024 May 16;14(1):11220. doi: 10.1038/s41598-024-61478-5. Sci Rep. 2024. PMID: 38755206 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
