Fasting in healthy subjects is associated with intrahepatic accumulation of lipids as assessed by 1H-magnetic resonance spectroscopy
- PMID: 17990983
- DOI: 10.1042/CS20070217
Fasting in healthy subjects is associated with intrahepatic accumulation of lipids as assessed by 1H-magnetic resonance spectroscopy
Abstract
The impact of fasting on IHL (intrahepatic lipid) content in human subjects has not been investigated previously, but results indicate that it may change rapidly in response to metabolic cues. The aim of the present study was to measure IHL content after fasting and to correlate this with circulating lipid intermediates. A total of eight healthy non-obese young males were studied before and after 12 or 36 h of fasting. IHL content was assessed by (1)H-magnetic resonance spectroscopy, and blood samples were drawn after the fasting period. IHL content increased significantly after the 36 h fasting period [median increase 156% (range, 4-252%); P<0.05]. Furthermore, a significant positive correlation between this increase and 3-hydroxybutyrate concentration was detected (P=0.03). No significant change in IHL content was demonstrated after the 12 h fasting period. The baseline median inter-individual variation in IHLs was 0.51% (range, 0.25-0.72%). The coefficient of variation of IHL measurements was 11.6%; 25-30% of the variation was of analytical origin and the remaining 70-75% was attributed to repositioning. In conclusion, IHL content increases in healthy male subjects during fasting, which demonstrates that nutritional status should be accounted for when assessing IHLs in clinical studies. Moreover, the increase in IHLs was positively correlated with the concentration of 3-hydroxybutyrate.
Comment in
-
Is adipose tissue lipolysis always an adaptive response to starvation?: implications for non-alcoholic fatty liver disease.Clin Sci (Lond). 2008 Apr;114(8):543-5. doi: 10.1042/CS20070461. Clin Sci (Lond). 2008. PMID: 18181765 Review.
Similar articles
-
Fasting for 72 h increases intramyocellular lipid content in nondiabetic, physically fit men.Am J Physiol Endocrinol Metab. 2002 Dec;283(6):E1185-91. doi: 10.1152/ajpendo.00108.2002. Epub 2002 Jul 30. Am J Physiol Endocrinol Metab. 2002. PMID: 12388154 Clinical Trial.
-
Muscle type dependent increase in intramyocellular lipids during prolonged fasting of human subjects: a proton MRS study.Horm Metab Res. 2004 Sep;36(9):639-44. doi: 10.1055/s-2004-825928. Horm Metab Res. 2004. PMID: 15486816
-
Is adipose tissue lipolysis always an adaptive response to starvation?: implications for non-alcoholic fatty liver disease.Clin Sci (Lond). 2008 Apr;114(8):543-5. doi: 10.1042/CS20070461. Clin Sci (Lond). 2008. PMID: 18181765 Review.
-
Eicosapentaenoic acid decreases postprandial beta-hydroxybutyrate and free fatty acid responses in healthy young and elderly.Nutrition. 2009 Mar;25(3):289-94. doi: 10.1016/j.nut.2008.09.006. Epub 2008 Nov 26. Nutrition. 2009. PMID: 19036560
-
Metabolic MRI of myocardial and hepatic triglyceride content in response to nutritional interventions.Curr Opin Clin Nutr Metab Care. 2008 Sep;11(5):573-9. doi: 10.1097/MCO.0b013e32830a98e3. Curr Opin Clin Nutr Metab Care. 2008. PMID: 18685452 Review.
Cited by
-
Intermittent Energy Restriction, Weight Loss and Cardiometabolic Risk: A Critical Appraisal of Evidence in Humans.Healthcare (Basel). 2021 Apr 22;9(5):495. doi: 10.3390/healthcare9050495. Healthcare (Basel). 2021. PMID: 33922103 Free PMC article. Review.
-
Fasting induces hepatic lipid accumulation by stimulating peroxisomal dicarboxylic acid oxidation.J Biol Chem. 2021 Jan-Jun;296:100622. doi: 10.1016/j.jbc.2021.100622. Epub 2021 Mar 31. J Biol Chem. 2021. PMID: 33811861 Free PMC article.
-
Contrasting Effects of Fasting on Liver-Adipose Axis in Alcohol-Associated and Non-alcoholic Fatty Liver.Front Physiol. 2021 Mar 3;12:625352. doi: 10.3389/fphys.2021.625352. eCollection 2021. Front Physiol. 2021. PMID: 33746771 Free PMC article.
-
Acute exercise in mice transiently remodels the hepatic lipidome in an intensity-dependent manner.Lipids Health Dis. 2020 Oct 8;19(1):219. doi: 10.1186/s12944-020-01395-4. Lipids Health Dis. 2020. PMID: 33032600 Free PMC article.
-
In Vivo Fat Quantification: Monitoring Effects of a 6-Week Non-Energy-Restricted Ketogenic Diet in Healthy Adults Using MRI, ADP and BIA.Nutrients. 2020 Jan 17;12(1):244. doi: 10.3390/nu12010244. Nutrients. 2020. PMID: 31963475 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources