Type 1 diabetes as a relapsing-remitting disease?
- PMID: 17982429
- DOI: 10.1038/nri2192
Type 1 diabetes as a relapsing-remitting disease?
Abstract
Chronic immunological processes that underlie persistent viral infections and autoimmune disorders such as multiple sclerosis can be relapsing-remitting in nature. The progressive loss of beta-cell mass during the development of autoimmune type 1 diabetes (T1D) can also be non-linear, but the exact nature and kinetics of the immunological processes that govern T1D are not known. Here, we propose that the immunological process that is at the root of T1D is relapsing-remitting in nature and discuss the unresolved controversies and therapeutic implications of this hypothesis.
Similar articles
-
Disease-modifying immunotherapy for the management of autoimmune diabetes.Neuroimmunomodulation. 2010;17(3):173-6. doi: 10.1159/000258716. Epub 2010 Feb 4. Neuroimmunomodulation. 2010. PMID: 20134195 Review.
-
'Sensing' autoimmunity in type 1 diabetes.Trends Mol Med. 2007 Oct;13(10):405-13. doi: 10.1016/j.molmed.2007.07.006. Epub 2007 Sep 27. Trends Mol Med. 2007. PMID: 17900987 Review.
-
Rehabilitation of adaptive immunity and regeneration of beta cells.Trends Biotechnol. 2006 Nov;24(11):516-22. doi: 10.1016/j.tibtech.2006.08.007. Epub 2006 Sep 11. Trends Biotechnol. 2006. PMID: 16963140 Review.
-
The role of low avidity T cells in the protection against type 1 diabetes: a modeling investigation.J Theor Biol. 2009 Jan 7;256(1):126-41. doi: 10.1016/j.jtbi.2008.09.019. Epub 2008 Oct 6. J Theor Biol. 2009. PMID: 18950644
-
CD8+ T cells in type 1 diabetes.Adv Immunol. 2008;100:79-124. doi: 10.1016/S0065-2776(08)00804-3. Adv Immunol. 2008. PMID: 19111164 Review.
Cited by
-
Autoimmune CD8+ T cells in type 1 diabetes: from single-cell RNA sequencing to T-cell receptor redirection.Front Endocrinol (Lausanne). 2024 May 10;15:1377322. doi: 10.3389/fendo.2024.1377322. eCollection 2024. Front Endocrinol (Lausanne). 2024. PMID: 38800484 Free PMC article. Review.
-
Reversal of diabetes by an oral Salmonella-based vaccine in acute and progressive diabetes in NOD mice.PLoS One. 2024 May 23;19(5):e0303863. doi: 10.1371/journal.pone.0303863. eCollection 2024. PLoS One. 2024. PMID: 38781241 Free PMC article.
-
Refined protocol for newly onset identification in non-obese diabetic mice: an animal-friendly, cost-effective, and efficient alternative.Lab Anim Res. 2024 Apr 22;40(1):16. doi: 10.1186/s42826-024-00202-w. Lab Anim Res. 2024. PMID: 38649958 Free PMC article.
-
Immunological and virological triggers of type 1 diabetes: insights and implications.Front Immunol. 2024 Jan 4;14:1326711. doi: 10.3389/fimmu.2023.1326711. eCollection 2023. Front Immunol. 2024. PMID: 38239343 Free PMC article. Review.
-
Excitable dynamics of flares and relapses in autoimmune diseases.iScience. 2023 Sep 27;26(11):108084. doi: 10.1016/j.isci.2023.108084. eCollection 2023 Nov 17. iScience. 2023. PMID: 37915612 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical