Selective increases of bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia
- PMID: 17823788
- DOI: 10.1007/s00125-007-0791-0
Selective increases of bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia
Abstract
Aims/hypothesis: Recent evidence suggests that a particular gut microbial community may favour occurrence of the metabolic diseases. Recently, we reported that high-fat (HF) feeding was associated with higher endotoxaemia and lower Bifidobacterium species (spp.) caecal content in mice. We therefore tested whether restoration of the quantity of caecal Bifidobacterium spp. could modulate metabolic endotoxaemia, the inflammatory tone and the development of diabetes.
Methods: Since bifidobacteria have been reported to reduce intestinal endotoxin levels and improve mucosal barrier function, we specifically increased the gut bifidobacterial content of HF-diet-fed mice through the use of a prebiotic (oligofructose [OFS]).
Results: Compared with normal chow-fed control mice, HF feeding significantly reduced intestinal Gram-negative and Gram-positive bacteria including levels of bifidobacteria, a dominant member of the intestinal microbiota, which is seen as physiologically positive. As expected, HF-OFS-fed mice had totally restored quantities of bifidobacteria. HF-feeding significantly increased endotoxaemia, which was normalised to control levels in HF-OFS-treated mice. Multiple-correlation analyses showed that endotoxaemia significantly and negatively correlated with Bifidobacterium spp., but no relationship was seen between endotoxaemia and any other bacterial group. Finally, in HF-OFS-treated-mice, Bifidobacterium spp. significantly and positively correlated with improved glucose tolerance, glucose-induced insulin secretion and normalised inflammatory tone (decreased endotoxaemia, plasma and adipose tissue proinflammatory cytokines).
Conclusions/interpretation: Together, these findings suggest that the gut microbiota contribute towards the pathophysiological regulation of endotoxaemia and set the tone of inflammation for occurrence of diabetes and/or obesity. Thus, it would be useful to develop specific strategies for modifying gut microbiota in favour of bifidobacteria to prevent the deleterious effect of HF-diet-induced metabolic diseases.
Comment in
-
The gut-liver-axis: endotoxemia, inflammation, insulin resistance and NASH.J Hepatol. 2008 Jun;48(6):1032-4. doi: 10.1016/j.jhep.2008.03.007. Epub 2008 Apr 3. J Hepatol. 2008. PMID: 18468548 No abstract available.
Similar articles
-
Bifidobacterium longum supplementation improved high-fat-fed-induced metabolic syndrome and promoted intestinal Reg I gene expression.Exp Biol Med (Maywood). 2011 Jul;236(7):823-31. doi: 10.1258/ebm.2011.010399. Epub 2011 Jun 17. Exp Biol Med (Maywood). 2011. PMID: 21685239
-
Prebiotic effects of wheat arabinoxylan related to the increase in bifidobacteria, Roseburia and Bacteroides/Prevotella in diet-induced obese mice.PLoS One. 2011;6(6):e20944. doi: 10.1371/journal.pone.0020944. Epub 2011 Jun 9. PLoS One. 2011. PMID: 21695273 Free PMC article.
-
Alleviation of high fat diet-induced obesity by oligofructose in gnotobiotic mice is independent of presence of Bifidobacterium longum.Mol Nutr Food Res. 2015 Nov;59(11):2267-78. doi: 10.1002/mnfr.201500249. Epub 2015 Aug 26. Mol Nutr Food Res. 2015. PMID: 26202344 Free PMC article.
-
Role of gut microflora in the development of obesity and insulin resistance following high-fat diet feeding.Pathol Biol (Paris). 2008 Jul;56(5):305-9. doi: 10.1016/j.patbio.2007.09.008. Epub 2008 Jan 30. Pathol Biol (Paris). 2008. PMID: 18178333 Review.
-
Gut microbiota controls adipose tissue expansion, gut barrier and glucose metabolism: novel insights into molecular targets and interventions using prebiotics.Benef Microbes. 2014 Mar;5(1):3-17. doi: 10.3920/BM2012.0065. Benef Microbes. 2014. PMID: 23886976 Review.
Cited by
-
Causal effect between gut microbiota and metabolic syndrome in European population: a bidirectional mendelian randomization study.Cell Biosci. 2024 May 28;14(1):67. doi: 10.1186/s13578-024-01232-6. Cell Biosci. 2024. PMID: 38807189 Free PMC article.
-
Omeprazole and risk of osteoarthritis: insights from a mendelian randomization study in the UK Biobank.J Transl Med. 2024 May 27;22(1):504. doi: 10.1186/s12967-024-05255-y. J Transl Med. 2024. PMID: 38802944 Free PMC article.
-
The Role of Prebiotics in Modulating Gut Microbiota: Implications for Human Health.Int J Mol Sci. 2024 Apr 29;25(9):4834. doi: 10.3390/ijms25094834. Int J Mol Sci. 2024. PMID: 38732060 Free PMC article. Review.
-
Can modulation of gut microbiota affect anthropometric indices in patients with non-alcoholic fatty liver disease? An umbrella meta-analysis of randomized controlled trials.Ann Med Surg (Lond). 2024 Jan 25;86(5):2900-2910. doi: 10.1097/MS9.0000000000001740. eCollection 2024 May. Ann Med Surg (Lond). 2024. PMID: 38694388 Free PMC article. Review.
-
Dose-Dependent Effects of Lipopolysaccharide on the Endothelium-Sepsis versus Metabolic Endotoxemia-Induced Cellular Senescence.Antioxidants (Basel). 2024 Apr 9;13(4):443. doi: 10.3390/antiox13040443. Antioxidants (Basel). 2024. PMID: 38671891 Free PMC article. Review.
References
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials
Miscellaneous