Review
doi: 10.1038/sj.ki.5002281.
Placental ischemia and soluble fms-like tyrosine kinase 1: cause or consequence of preeclampsia?
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- PMID: 17495934
- DOI: 10.1038/sj.ki.5002281
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Review
Placental ischemia and soluble fms-like tyrosine kinase 1: cause or consequence of preeclampsia?
Kidney Int.
2007 May.
Free article
Abstract
Elevated circulating soluble fms-like tyrosine kinase 1 (sFLT-1) is associated with the development of the clinical signs and symptoms of preeclampsia. Placental ischemia has been suggested as one of the etiological factors that mediate increased sFLT-1 production in patients with preeclampsia, but definitive evidence for this hypothesis was lacking. Makris et al. demonstrate that inducing placental ischemia in primates is sufficient to induce sFLT-1 upregulation and the clinical signs and symptoms of preeclampsia.
Comment on
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Uteroplacental ischemia results in proteinuric hypertension and elevated sFLT-1.Kidney Int. 2007 May;71(10):977-84. doi: 10.1038/sj.ki.5002175. Epub 2007 Mar 21. Kidney Int. 2007. PMID: 17377512
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