Heterogeneous effects of alcohol on dopamine release in the striatum: a PET study
- PMID: 17428296
- DOI: 10.1111/j.1530-0277.2007.00390.x
Heterogeneous effects of alcohol on dopamine release in the striatum: a PET study
Abstract
Background: A dopaminergic response to alcohol in humans has not been demonstrated consistently with positron emission tomography (PET). We hypothesized that the effect of alcohol on striatal dopamine (DA) release may be anatomically heterogeneous between subjects. Our approach was to identify voxels that exhibited alcohol-induced DA responses within the striatum, and to determine the relationships between DA responses and alcohol-related behavior.
Methods: A novel method was developed to examine the anatomic extent and magnitude of striatal DA responses to alcohol across subjects. Thirteen healthy control subjects underwent 2 PET scans with [11C]raclopride (1 at baseline, 1 with an i.v. alcohol infusion to a target breath alcohol concentration of either 60 or 80 mg%). Parametric images of striatal binding potential (BP) were used to create maps of change in BP (deltaBP, an index of changes in DA levels). The anatomic extent and magnitude of DA responses were determined with voxel extraction methods. Subjective responses ("High," "Intoxication") to the alcohol infusion and behavioral data from the 90-day time-line follow back were assessed for relationships with DA responses to alcohol.
Results: A voxel-wise t-test between baseline and alcohol BP images did not show any differences in D2/D3 receptor availability between the conditions. Data from the striatal deltaBP maps nevertheless showed that the anatomic extent and magnitude of alcohol-induced DA release in the striatum are correlated with subjective responses to alcohol.
Conclusions: The heterogeneity of dopaminergic responses to alcohol across subjects may be a reason for the lack of reports demonstrating DA involvement in alcohol-related behaviors. By allowing for different spatial patterns of DA release within each subject's striata, we showed correlations between alcohol-induced DA release in the striata and behavioral outcomes related to alcohol.
Similar articles
-
Alcohol promotes dopamine release in the human nucleus accumbens.Synapse. 2003 Sep 15;49(4):226-31. doi: 10.1002/syn.10226. Synapse. 2003. PMID: 12827641
-
Nonparametric extraction of transient changes in neurotransmitter concentration from dynamic PET data.IEEE Trans Med Imaging. 2007 Mar;26(3):359-73. doi: 10.1109/TMI.2006.891501. IEEE Trans Med Imaging. 2007. PMID: 17354641
-
Differences in IV alcohol-induced dopamine release in the ventral striatum of social drinkers and nontreatment-seeking alcoholics.Drug Alcohol Depend. 2016 Mar 1;160:163-9. doi: 10.1016/j.drugalcdep.2016.01.001. Epub 2016 Jan 13. Drug Alcohol Depend. 2016. PMID: 26832934 Free PMC article.
-
Cocaine abuse and sensitization of striatal dopamine transmission: a critical review of the preclinical and clinical imaging literature.Synapse. 2008 Nov;62(11):851-69. doi: 10.1002/syn.20566. Synapse. 2008. PMID: 18720516 Review.
-
Dopamine and Alcohol: A Review of in vivo PET and SPECT Studies.Neuropsychobiology. 2023;82(6):319-345. doi: 10.1159/000534620. Epub 2023 Nov 14. Neuropsychobiology. 2023. PMID: 37963449 Review.
Cited by
-
Associations between moderate alcohol consumption, brain iron, and cognition in UK Biobank participants: Observational and mendelian randomization analyses.PLoS Med. 2022 Jul 14;19(7):e1004039. doi: 10.1371/journal.pmed.1004039. eCollection 2022 Jul. PLoS Med. 2022. PMID: 35834561 Free PMC article.
-
The glycine-containing dipeptide leucine-glycine raises accumbal dopamine levels in a subpopulation of rats presenting a lower endogenous dopamine tone.J Neural Transm (Vienna). 2022 Apr;129(4):395-407. doi: 10.1007/s00702-022-02487-4. Epub 2022 Mar 24. J Neural Transm (Vienna). 2022. PMID: 35322277 Free PMC article.
-
Nicotine Patch Alters Patterns of Cigarette Smoking-Induced Dopamine Release: Patterns Relate to Biomarkers Associated With Treatment Response.Nicotine Tob Res. 2022 Oct 17;24(10):1597-1606. doi: 10.1093/ntr/ntac026. Nicotine Tob Res. 2022. PMID: 35100429 Free PMC article. Clinical Trial.
-
Reciprocal midbrain-extended amygdala circuit activity in preclinical models of alcohol use and misuse.Neuropharmacology. 2022 Jan 1;202:108856. doi: 10.1016/j.neuropharm.2021.108856. Epub 2021 Oct 25. Neuropharmacology. 2022. PMID: 34710467 Free PMC article. Review.
-
Alcohol Sensitivity as an Endophenotype of Alcohol Use Disorder: Exploring Its Translational Utility between Rodents and Humans.Brain Sci. 2020 Oct 13;10(10):725. doi: 10.3390/brainsci10100725. Brain Sci. 2020. PMID: 33066036 Free PMC article. Review.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources