Ten-year risk of cardiovascular incidence related to diabetes, prediabetes, and the metabolic syndrome
- PMID: 17383293
- DOI: 10.1016/j.ahj.2007.01.003
Ten-year risk of cardiovascular incidence related to diabetes, prediabetes, and the metabolic syndrome
Abstract
Background: The relative contributions of the metabolic syndrome (MetS) and dysglycemia on the risk of cardiovascular disease (CVD) have not been dissected. We aimed to compare MetS with dysglycemia in their association with the 10-year incidence risk of CVD.
Methods: A total of 30,378 subjects were recruited from 11 provinces in the CMCS and followed-up for new coronary heart disease (CHD) and stroke events (ischemic stroke and hemorrhagic stroke) for 10 years. Incidence rates and HRs were estimated by the presence or absence of MetS, impaired fasting glucose (IFG) and diabetes, and by the various traits of MetS.
Results: Among the subjects, 18.2% were defined as having MetS; 21.1% had IFG, and 6.8% had diabetes. Metabolic syndrome prevalence in IFG and diabetes was 38.1% and 48.7%, respectively, and the prevalence of IFG and diabetes in MetS was 44.1% and 18.3%, respectively. After adjusting for nonmetabolic risk factors, HRs of total CVD, CHD, and ischemic stroke in MetS were significant and higher than those in non-MetS, regardless of glycemic status. In the absence of MetS, the impact of dysglycemia was found only in IFG to CHD and diabetes to ischemic stroke. Hyperglycemia without any concomitant disorders was not associated with significantly higher risk of CVD.
Conclusions: The increased CVD risk in individuals with IFG or diabetes was largely driven by the coexistence of multiple metabolic disorders rather than hyperglycemia per se. Identification of clustering of metabolic abnormalities should be given more consideration in CVD prevention.
Similar articles
-
Impact of metabolic syndrome, diabetes and prediabetes on cardiovascular events: Tehran lipid and glucose study.Diabetes Res Clin Pract. 2010 Mar;87(3):342-7. doi: 10.1016/j.diabres.2009.11.010. Epub 2009 Dec 8. Diabetes Res Clin Pract. 2010. PMID: 20004035
-
The metabolic syndrome predicts cardiovascular mortality: a 13-year follow-up study in elderly non-diabetic Finns.Eur Heart J. 2007 Apr;28(7):857-64. doi: 10.1093/eurheartj/ehl524. Epub 2007 Feb 15. Eur Heart J. 2007. PMID: 17303589
-
Prevalence and prognostic impact of subclinical cardiovascular disease in individuals with the metabolic syndrome and diabetes.Diabetes. 2007 Jun;56(6):1718-26. doi: 10.2337/db07-0078. Epub 2007 Mar 16. Diabetes. 2007. PMID: 17369522
-
From hyperglycemia to the risk of cardiovascular disease.Rev Cardiovasc Med. 2006;7 Suppl 2:S3-9. Rev Cardiovasc Med. 2006. PMID: 17224875 Review.
-
The metabolic syndrome and cardiovascular disease.Ann Med. 2006;38(1):64-80. doi: 10.1080/07853890500401234. Ann Med. 2006. PMID: 16448990 Review.
Cited by
-
Association between the AHA life's essential 8 and prediabetes/diabetes: a cross-sectional NHANES study.Front Endocrinol (Lausanne). 2024 Jul 1;15:1376463. doi: 10.3389/fendo.2024.1376463. eCollection 2024. Front Endocrinol (Lausanne). 2024. PMID: 39086898 Free PMC article.
-
Prevalence of prediabetes and risk of CVD mortality in individuals with prediabetes alone or plus hypertension in Northeast China: insight from a population based cohort study.BMC Public Health. 2024 Feb 15;24(1):475. doi: 10.1186/s12889-024-17996-y. BMC Public Health. 2024. PMID: 38360567 Free PMC article.
-
Risk Factors for Coronary Artery Calcifications in Overweight or Obese Persons with Prediabetes: Can They Predict T2 Diabetes and Coronary Vascular Events?J Clin Med. 2023 Jun 8;12(12):3915. doi: 10.3390/jcm12123915. J Clin Med. 2023. PMID: 37373609 Free PMC article.
-
Ten-year atherosclerotic cardiovascular disease risk prediction for postmenopausal women: Impacts of isolated postchallenge hyperglycemia.Medicine (Baltimore). 2022 Sep 9;101(36):e30352. doi: 10.1097/MD.0000000000030352. Medicine (Baltimore). 2022. PMID: 36086734 Free PMC article.
-
Key process features of personalized diet counselling in metabolic syndrome: secondary analysis of feasibility study in primary care.BMC Nutr. 2022 May 9;8(1):45. doi: 10.1186/s40795-022-00540-9. BMC Nutr. 2022. PMID: 35534841 Free PMC article.