Pathohistological classification of pituitary tumors: 10 years of experience with the German Pituitary Tumor Registry
- PMID: 17287410
- DOI: 10.1530/eje.1.02326
Pathohistological classification of pituitary tumors: 10 years of experience with the German Pituitary Tumor Registry
Abstract
In 1996, the German Registry of Pituitary Tumors was founded by the Pituitary Section of the German Society of Endocrinology as a reference center for collection and consultant pathohistological studies of pituitary tumors. The experiences of the first 10 years of this registry based on 4122 cases will herein be reported. The data supplement former collections of the years 1970-1995 with 3480 surgically removed tumors or lesions of the pituitary region. The cases were studied using histology, immunostainings and in some cases also molecular pathology or electron microscopy. The adenomas were classified according to the current World Health Organization classification in the version of 2004. From 1996 on 3489 adenomas (84.6%), 5 pituitary carcinomas (0.12%), 133 craniopharyngiomas (3.2%), 39 meningiomas (0.94%), 25 metastases (0.6%), 22 chordomas (0.5%), 115 cystic non-neoplastic lesions (2.8%), and 46 inflammatory lesions (1.1%, 248 other lesions or normal tissue (6.0%)) were collected by us. The adenomas (100%) were classified into densely granulated GH cell adenomas (9.2%), sparsely granulated GH cell adenomas (6.3%), sparsely granulated prolactin (PRL) cell adenomas (8.9%), densely granulated PRL cell adenomas (0.3%), mixed GH/PRL cell adenomas (5.2%), mammosomatotropic adenomas (1.1%), acidophilic stem cell adenomas (0.2%), densely granulated ACTH cell adenomas (7.2%), sparsely granulated ACTH cell adenomas (7.9%), Crooke cell adenomas (0.03%), TSH cell adenomas (1.5%), FSH/LH cell adenomas (24.8%), null cell adenomas (19.3%), null cell adenoma, oncocytic variant (5.8%), and plurihormonal adenomas (1.3%). Following the WHO classification of 2004, the new entity 'atypical adenoma' was found in 12 cases in 2005. Various prognostic parameters and clinical implications are discussed.
Similar articles
-
Clinical Impact of the Current WHO Classification of Pituitary Adenomas.Endocr Pathol. 2016 Jun;27(2):104-14. doi: 10.1007/s12022-016-9418-7. Endocr Pathol. 2016. PMID: 26860936 Review.
-
Subclinical adenomas in postmortem pituitaries: classification and correlations to clinical data.Eur J Endocrinol. 2006 May;154(5):753-8. doi: 10.1530/eje.1.02107. Eur J Endocrinol. 2006. PMID: 16645024
-
[Pituitary gland tumors].Pathologe. 2003 Jul;24(4):255-64. doi: 10.1007/s00292-003-0625-x. Epub 2003 May 29. Pathologe. 2003. PMID: 14513271 Review. German.
-
Current pathological classification of pituitary adenomas.Acta Neurochir Suppl. 1996;65:1-3. doi: 10.1007/978-3-7091-9450-8_1. Acta Neurochir Suppl. 1996. PMID: 8738481 Review.
-
A clinicomorphological study of pituitary tumors associated with the clinical syndrome of acromegaly.Exp Clin Endocrinol. 1991;98(3):223-7. doi: 10.1055/s-0029-1211121. Exp Clin Endocrinol. 1991. PMID: 1778242
Cited by
-
Long-term outcome of surgically treated and conservatively managed Rathke cleft cysts.Acta Neurochir (Wien). 2024 Apr 1;166(1):159. doi: 10.1007/s00701-024-06052-8. Acta Neurochir (Wien). 2024. PMID: 38557782 Free PMC article.
-
Machine Learning Analysis of Post-Operative Tumour Progression in Non-Functioning Pituitary Neuroendocrine Tumours: A Pilot Study.Cancers (Basel). 2024 Mar 19;16(6):1199. doi: 10.3390/cancers16061199. Cancers (Basel). 2024. PMID: 38539533 Free PMC article.
-
Transcriptome Analysis Reveals Distinct Patterns Between the Invasive and Noninvasive Pituitary Neuroendocrine Tumors.J Endocr Soc. 2024 Mar 1;8(5):bvae040. doi: 10.1210/jendso/bvae040. eCollection 2024 Mar 12. J Endocr Soc. 2024. PMID: 38505563 Free PMC article.
-
Chronic lymphocytic leukemia/small lymphocytic lymphoma arising in the pituitary gland: illustrative case.J Neurosurg Case Lessons. 2024 Mar 4;7(10):CASE23773. doi: 10.3171/CASE23773. Print 2024 Mar 4. J Neurosurg Case Lessons. 2024. PMID: 38437681 Free PMC article.
-
Consensus guideline for the diagnosis and management of pituitary adenomas in childhood and adolescence: Part 2, specific diseases.Nat Rev Endocrinol. 2024 May;20(5):290-309. doi: 10.1038/s41574-023-00949-7. Epub 2024 Feb 9. Nat Rev Endocrinol. 2024. PMID: 38336898 Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical