Messing with bacterial quorum sensing
- PMID: 17158701
- PMCID: PMC1698510
- DOI: 10.1128/MMBR.00002-06
Messing with bacterial quorum sensing
Abstract
Quorum sensing is widely recognized as an efficient mechanism to regulate expression of specific genes responsible for communal behavior in bacteria. Several bacterial phenotypes essential for the successful establishment of symbiotic, pathogenic, or commensal relationships with eukaryotic hosts, including motility, exopolysaccharide production, biofilm formation, and toxin production, are often regulated by quorum sensing. Interestingly, eukaryotes produce quorum-sensing-interfering (QSI) compounds that have a positive or negative influence on the bacterial signaling network. This eukaryotic interference could result in further fine-tuning of bacterial quorum sensing. Furthermore, recent work involving the synthesis of structural homologs to the various quorum-sensing signal molecules has resulted in the development of additional QSI compounds that could be used to control pathogenic bacteria. The creation of transgenic plants that express bacterial quorum-sensing genes is yet another strategy to interfere with bacterial behavior. Further investigation on the manipulation of quorum-sensing systems could provide us with powerful tools against harmful bacteria.
Figures
![FIG. 1.](https://cdn.statically.io/img/www.ncbi.nlm.nih.gov/pmc/articles/instance/1698510/bin/zmr0040621360001.gif)
![FIG. 2.](https://cdn.statically.io/img/www.ncbi.nlm.nih.gov/pmc/articles/instance/1698510/bin/zmr0040621360002.gif)
Similar articles
-
Quorum sensing: a primer for food microbiologists.J Food Prot. 2004 May;67(5):1053-70. doi: 10.4315/0362-028x-67.5.1053. J Food Prot. 2004. PMID: 15151251 Review.
-
Quorum sensing in bacteria.Annu Rev Microbiol. 2001;55:165-99. doi: 10.1146/annurev.micro.55.1.165. Annu Rev Microbiol. 2001. PMID: 11544353 Review.
-
Role of Heat Shock Proteases in Quorum-Sensing-Mediated Regulation of Biofilm Formation by Vibrio Species.mBio. 2018 Jan 2;9(1):e02086-17. doi: 10.1128/mBio.02086-17. mBio. 2018. PMID: 29295912 Free PMC article.
-
L-Canavanine made by Medicago sativa interferes with quorum sensing in Sinorhizobium meliloti.J Bacteriol. 2005 Dec;187(24):8427-36. doi: 10.1128/JB.187.24.8427-8436.2005. J Bacteriol. 2005. PMID: 16321947 Free PMC article.
-
Quorum sensing of bacteria and trans-kingdom interactions of N-acyl homoserine lactones with eukaryotes.J Chem Ecol. 2012 Jun;38(6):704-13. doi: 10.1007/s10886-012-0141-7. Epub 2012 May 31. J Chem Ecol. 2012. PMID: 22648507 Review.
Cited by
-
Soybean-mediated suppression of BjaI/BjaR1 quorum sensing in Bradyrhizobium diazoefficiens impacts symbiotic nitrogen fixation.Appl Environ Microbiol. 2024 Feb 21;90(2):e0137423. doi: 10.1128/aem.01374-23. Epub 2024 Jan 22. Appl Environ Microbiol. 2024. PMID: 38251894
-
Bile effects on the Pseudomonas aeruginosa pathogenesis in cystic fibrosis patients with gastroesophageal reflux.Heliyon. 2023 Nov 10;9(11):e22111. doi: 10.1016/j.heliyon.2023.e22111. eCollection 2023 Nov. Heliyon. 2023. PMID: 38034726 Free PMC article. Review.
-
New Strategies for Biocontrol of Bacterial Toxins and Virulence: Focusing on Quorum-Sensing Interference and Biofilm Inhibition.Toxins (Basel). 2023 Sep 15;15(9):570. doi: 10.3390/toxins15090570. Toxins (Basel). 2023. PMID: 37755996 Free PMC article. Review.
-
RpoZ regulates 2,4-DAPG production and quorum sensing system in Pseudomonas fluorescens 2P24.Front Microbiol. 2023 May 12;14:1160913. doi: 10.3389/fmicb.2023.1160913. eCollection 2023. Front Microbiol. 2023. PMID: 37250031 Free PMC article.
-
Disruption of Biofilm Formation and Quorum Sensing in Pathogenic Bacteria by Compounds from Zanthoxylum Gilletti (De Wild) P.G. Waterman.Appl Biochem Biotechnol. 2023 Oct;195(10):6113-6131. doi: 10.1007/s12010-023-04380-6. Epub 2023 Feb 22. Appl Biochem Biotechnol. 2023. PMID: 36811771
References
-
- Aendekerk, S., B. Ghysels, P. Cornelis, and C. Baysse. 2002. Characterization of a new efflux pump, MexGHI-OpmD, from Pseudomonas aeruginosa that confers resistance to vanadium. Microbiology 148:2371-2381. - PubMed
-
- Barber, C. E., J. L. Tang, J. X. Feng, M. Q. Pan, T. J. Wilson, H. Slater, J. M. Dow, P. Williams, and M. J. Daniels. 1997. A novel regulatory system required for pathogenicity of Xanthomonas campestris is mediated by a small diffusible signal molecule. Mol. Microbiol. 24:555-566. - PubMed
-
- Bassler, B. L. 1999. How bacteria talk to each other: regulation of gene expression by quorum sensing. Curr. Opin. Microbiol. 2:582-587. - PubMed
-
- Bassler, B. L. 2002. Small talk. Cell-to-cell communication in bacteria. Cell 109:421-424. - PubMed
-
- Bassler, B. L., M. Wright, R. E. Showalter, and M. R. Silverman. 1993. Intercellular signaling in Vibrio harveyi: sequence and function of genes regulating expression of luminescence. Mol. Microbiol. 9:773-786. - PubMed
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources