Early manifestation of type 1 diabetes in children is a risk factor for changed bone geometry: data using peripheral quantitative computed tomography
- PMID: 16908617
- DOI: 10.1542/peds.2005-2193
Early manifestation of type 1 diabetes in children is a risk factor for changed bone geometry: data using peripheral quantitative computed tomography
Abstract
Objective: Normal to severely decreased bone mineral density has been reported in children with type 1 diabetes. To detect possible abnormalities in bone mineralization, geometry, and muscle bone unit, we measured selective parameters in children with type 1 diabetes using peripheral quantitative computed tomography.
Methods: Measurements of the radius by peripheral quantitative computed tomography were made to assess cortical and trabecular bone characteristics as well as muscle mass in 88 patients (42 girls, 46 boys) at a mean age of 11.7 +/- 3.0 years, a mean disease duration of 5.6 +/- 3.7 years, and a mean manifestation age of type 1 diabetes of 6.1 +/- 3.5 years. Height, weight, Tanner stage, insulin regimen, and glycosylated hemoglobin values were recorded. Bone metabolism was studied by measurement of bone formation and bone resorption parameters. Dynamic muscle force was measured using a grip strength device.
Results: Overall, cortical, trabecular, and total bone mineral density were within the reference range. Total and cortical bone cross-sectional area and muscle mass were low in prepubertal patients, and total cross-sectional area was low in early puberty. Adolescent patients showed normal bone and muscle parameters. Grip strength and recreational physical activity were normal in all in relation to a healthy reference population. In a subgroup of 18 patients, early manifestation of type 1 diabetes was detected as a risk factor for altered bone development with significantly reduced cortical bone mineral density and total, cortical, and muscle cross-sectional area (-0.9 +/- 1.3 SD, -2.1 +/- 1.3 SD, -1.6 +/- 0.7 SD, and -1.0 +/- 0.7 SD, respectively). Bone characteristics were not influenced by metabolic control, disease duration, or insulin regimen.
Conclusions: Manifestation of type 1 diabetes at an early age may impair bone development. Longitudinal data are needed to determine whether this impairment persists into adolescence and adulthood.
Similar articles
-
Bone Density, Geometry, and Mass by Peripheral Quantitative Computed Tomography and Bone Turnover Markers in Children with Diabetes Mellitus Type 1.J Diabetes Res. 2022 Apr 18;2022:9261512. doi: 10.1155/2022/9261512. eCollection 2022. J Diabetes Res. 2022. PMID: 35480630 Free PMC article.
-
MECHANISMS IN ENDOCRINOLOGY: Mechanisms and evaluation of bone fragility in type 1 diabetes mellitus.Eur J Endocrinol. 2016 Apr;174(4):R127-38. doi: 10.1530/EJE-15-0820. Epub 2015 Nov 4. Eur J Endocrinol. 2016. PMID: 26537861 Review.
-
[Morphological analysis of bone dynamics and metabolic bone. Characteristics of bone morphometry and bone geometry in patients with type 2 diabetes].Clin Calcium. 2011 Apr;21(4):598-602. Clin Calcium. 2011. PMID: 21447929 Review. Japanese.
-
Long-term development of bone geometry and muscle in pediatric inflammatory bowel disease.Am J Gastroenterol. 2011 May;106(5):988-98. doi: 10.1038/ajg.2010.495. Epub 2011 Jan 11. Am J Gastroenterol. 2011. PMID: 21224841
-
Bone geometry and density in the skeleton of pre-pubertal gymnasts and school children.Bone. 2005 Jun;36(6):1012-8. doi: 10.1016/j.bone.2005.03.001. Bone. 2005. PMID: 15876561
Cited by
-
Lifestyle and physical fitness in adolescents with type 1 diabetes and obesity.Heliyon. 2023 Jan 21;9(1):e13109. doi: 10.1016/j.heliyon.2023.e13109. eCollection 2023 Jan. Heliyon. 2023. PMID: 36711296 Free PMC article.
-
Higher Body Fat in Children and Adolescents With Type 1 Diabetes-A Systematic Review and Meta-Analysis.Front Pediatr. 2022 Jun 24;10:911061. doi: 10.3389/fped.2022.911061. eCollection 2022. Front Pediatr. 2022. PMID: 35813369 Free PMC article.
-
Childhood type 1 diabetes is associated with abnormal bone development.Pediatr Diabetes. 2022 Sep;23(6):773-782. doi: 10.1111/pedi.13367. Epub 2022 Jun 6. Pediatr Diabetes. 2022. PMID: 35603554 Free PMC article.
-
Bone Density, Geometry, and Mass by Peripheral Quantitative Computed Tomography and Bone Turnover Markers in Children with Diabetes Mellitus Type 1.J Diabetes Res. 2022 Apr 18;2022:9261512. doi: 10.1155/2022/9261512. eCollection 2022. J Diabetes Res. 2022. PMID: 35480630 Free PMC article.
-
Bone Mineral Density and Type 1 Diabetes in Children and Adolescents: A Meta-analysis.Diabetes Care. 2021 Aug;44(8):1898-1905. doi: 10.2337/dc20-3128. Epub 2021 Jul 20. Diabetes Care. 2021. PMID: 34285100 Free PMC article. Review.
MeSH terms
LinkOut - more resources
Full Text Sources
Medical