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. 2006 Jun;117(6):e1111-8.
doi: 10.1542/peds.2005-1532. Epub 2006 May 8.

Improvement in risk factors for metabolic syndrome and insulin resistance in overweight youth who are treated with lifestyle intervention

Roshanak Monzavi  1 , Daina Dreimane, Mitchell E Geffner, Sharon Braun, Barry Conrad, Mary Klier, Francine R Kaufman
Affiliations

Improvement in risk factors for metabolic syndrome and insulin resistance in overweight youth who are treated with lifestyle intervention

Roshanak Monzavi et al. Pediatrics. 2006 Jun.

Abstract

Objective: To evaluate the prevalence of risk factors that are associated with the metabolic syndrome and insulin resistance in overweight youth and to determine the effect of a short-term, family-centered, lifestyle intervention on various associated anthropometric and metabolic measures.

Methods: Overweight youth who were between 8 and 16 years of age participated in a 12-week, family-centered, lifestyle intervention program. Anthropometric and metabolic measures were assessed before the program in all participants (n = 109) and after the program in a subset of the participants (n = 43).

Results: At baseline, 49.5% of youth had multiple risk factors associated with the metabolic syndrome, based on a modified definition of the National Cholesterol Education Program, and 10% had impaired fasting glucose and/or impaired glucose tolerance. Measures of insulin resistance correlated significantly with the risk factors of the metabolic syndrome. Forty-three youth had pre- and postintervention evaluations that showed statistically significant improvements in body mass index, systolic blood pressure, lipids (total, low-density lipoprotein cholesterol, and triglycerides), postprandial glucose, and leptin levels.

Conclusion: Overweight youth have multiple risk factors associated with the metabolic syndrome. A 12-week lifestyle program may have a positive effect on reducing risk factors for the metabolic syndrome and insulin resistance in overweight youth.

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