Estimating the prevalence and impact of antidepressant-induced sexual dysfunction in 2 European countries: a cross-sectional patient survey
- PMID: 16566614
- DOI: 10.4088/jcp.v67n0205
Estimating the prevalence and impact of antidepressant-induced sexual dysfunction in 2 European countries: a cross-sectional patient survey
Abstract
Objective: Sexual dysfunction is a common side effect of antidepressant treatment, but recognition of the problem is variable. The aim of this study was to estimate the prevalence and impact of sexual dysfunction during antidepressant treatment in 2 European countries.
Method: A cross-sectional survey of 502 adults in France and the United Kingdom. All participants were diagnosed with depression and taking a selective serotonin reuptake inhibitor (SSRI) or serotonin-norepinephrine reuptake inhibitor (SNRI), starting within the previous 3 months. Information was gathered about other medications and conditions known to impair sexual functioning, recent changes in sexual functioning, and the impact of any changes. The Medical Outcomes Study 12-Item Short-Form Health Survey and the Arizona Sexual Experience Scale were administered to measure health status and sexual functioning. Data were collected from June to July of 2002.
Results: Applying a prevalence estimate algorithm, 26.6% of the French sample and 39.2% of the U.K. sample were classified as having antidepressant-induced sexual dysfunction; 34.2% of men and 32.5% of women were classified with antidepressant-induced sexual dysfunction. There was no clear pattern of antidepressant-induced sexual dysfunction related to specific antidepressants. Patients with antidepressant-induced sexual dysfunction reported that changes in sexual functioning negatively affected their self-esteem, mood, and relationships with sexual partners. 23.8% of the French sample and 25.2% of the U.K. sample reported that they perceived that their partner was dissatisfied with their sex life.
Conclusion: The prevalence of antidepressant-induced sexual dysfunction in this study is similar to previous estimates reported in the literature. The impact of antidepressant-induced sexual dysfunction is substantial and negatively affects quality of life, self-esteem, mood, and relationships with sexual partners.
Similar articles
-
Prevalence and impact of antidepressant-associated sexual dysfunction in three European countries: replication in a cross-sectional patient survey.J Psychopharmacol. 2010 Apr;24(4):489-96. doi: 10.1177/0269881109102779. Epub 2009 Mar 27. J Psychopharmacol. 2010. PMID: 19329551
-
Prevalence of sexual dysfunction among newer antidepressants.J Clin Psychiatry. 2002 Apr;63(4):357-66. doi: 10.4088/jcp.v63n0414. J Clin Psychiatry. 2002. PMID: 12000211
-
Antidepressant-induced sexual dysfunction during treatment with moclobemide, paroxetine, sertraline, and venlafaxine.J Clin Psychiatry. 2000 Apr;61(4):276-81. doi: 10.4088/jcp.v61n0406. J Clin Psychiatry. 2000. PMID: 10830148
-
Antidepressant-induced sexual dysfunction.Ann Pharmacother. 2002 Oct;36(10):1577-89. doi: 10.1345/aph.1A195. Ann Pharmacother. 2002. PMID: 12243609 Review.
-
Sexual side effects of antidepressants.J Clin Psychiatry. 2000;61 Suppl 11:28-36. J Clin Psychiatry. 2000. PMID: 10926052 Review.
Cited by
-
Paraphilic disorders, psychopathy, and those who sexually offend: a narrative review of treatment modalities.Int J Impot Res. 2023 Dec 30. doi: 10.1038/s41443-023-00816-z. Online ahead of print. Int J Impot Res. 2023. PMID: 38160223 Review.
-
Efficacy, Safety, and Tolerability of Ansofaxine (LY03005) Extended-Release Tablet for Major Depressive Disorder: A Randomized, Double-Blind, Placebo-Controlled, Dose-Finding, Phase 2 Clinical Trial.Int J Neuropsychopharmacol. 2022 Mar 17;25(3):252-260. doi: 10.1093/ijnp/pyab074. Int J Neuropsychopharmacol. 2022. PMID: 34747448 Free PMC article. Clinical Trial.
-
Multifaceted Sexual Dysfunction in Dialyzing Men and Women: Pathophysiology, Diagnostics, and Therapeutics.Life (Basel). 2021 Apr 2;11(4):311. doi: 10.3390/life11040311. Life (Basel). 2021. PMID: 33918412 Free PMC article. Review.
-
The Use of Antidepressant Drugs in Climacteric Syndrome.Rev Bras Ginecol Obstet. 2020 Jan;42(1):1-4. doi: 10.1055/s-0040-1701457. Epub 2020 Feb 27. Rev Bras Ginecol Obstet. 2020. PMID: 32107759 Free PMC article. No abstract available.
-
Sexual functioning in females with depression in remission receiving escitalopram.Indian J Med Res. 2019 Dec;150(6):606-611. doi: 10.4103/ijmr.IJMR_1991_17. Indian J Med Res. 2019. PMID: 32048624 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical